Basic information
- Name:
Phosphonic difluoride,P-methyl-
- CAS No.:
676-99-3
- Molecular Structure:
- Formula:
- CH3 F2 O P
- Molecular Weight:
- 100.01
- Synonyms:
- Phosphonicdifluoride, methyl- (6CI,7CI,8CI,9CI); Difluoromethylphosphine oxide; Methyldifluorophosphite; Methylphosphonic difluoride; Methylphosphonyldifluoride
- Safety Description:
- Poison by inhalation and intravenous routes. When heated to decomposition it emits toxic fumes of POx and F−. See also FLUORIDES. Details
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Chemistry
The IUPAC name of Methylphosphonyl difluoride (CAS NO.676-99-3): Difluorophosphorylmethane
Synonyms: Difluoro ; Difluoromethylphosphine oxide ; Difluoromethylphosphineoxide ; Methyl difluorophosphite ; Methyldifluorophosphite ; Methylphosphonic difluoride ; Methylphosphonicaciddifluoride ; Methyl-phosphonicaciddifluoride
CAS: 676-99-3
Molecular Weight: 100.004487 g/mol
Molecular Formula: CH3F2OP
Molecular Structure:
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Index of Refraction: 1.276
Density: 1.248 g/cm3
Boiling Point: 55.4 °C at 760 mmHg
Toxicity Data With Reference
The toxicity of Methylphosphonyl difluoride (CAS NO.676-99-3):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LCLo | inhalation | 1842mg/m3/30M (1842mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969. |
| dog | LD50 | intravenous | 25800ug/kg (25.8mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| guinea pig | LCLo | inhalation | 1600mg/m3 (1600mg/m3) | Toxicologist. Vol. 4, Pg. 22, 1984. | |
| monkey | LCLo | inhalation | 2608mg/m3/30M (2608mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969. |
| monkey | LD50 | intravenous | 26900ug/kg (26.9mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| mouse | LCLo | inhalation | 1842mg/m3/30M (1842mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969. |
| mouse | LD50 | intravenous | 114mg/kg (114mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| rat | LCLo | inhalation | 1842mg/m3/30M (1842mg/m3) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969. |
| rat | LD50 | intravenous | 13700ug/kg (13.7mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
The Risk Statements Methylphosphonyl difluoride (CAS NO.676-99-3):
R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:S23:Do not breathe vapour. S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Poison by inhalation and intravenous routes. When heated to decomposition it emits toxic fumes of POx and F−. See also FLUORIDES.