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Name	Mildronate	EINECS	682-135-0
CAS No.	76144-81-5	Density	N/A
PSA	N/A	LogP	N/A
Solubility	N/A	Melting Point	85-90 °C
Formula	C₆H₁₄N₂O₂	Boiling Point	N/A
Molecular Weight	146.189	Flash Point	N/A
Transport Information	N/A	Appearance	White crystalline powder
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	3-(trimethylammonioamino)propanoate;Meldonium [INN];Hydrazinium,2-(2-carboxyethyl)-1,1,1- trimethyl-,inner salt;2-(2-Carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt;Quaterin;Kvaterin;Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, hydroxide, inner salt;MET 88;Meldonium;	Article Data	7

Mildronate Chemical Properties

Molecular Structure:

Molecular Formula: C₆H₁₄N₂O₂
Molecular Weight: 146.1876
CAS NO: 76144-81-5
Melting point: 85-90 °C
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 4
Polar Surface Area: 40.54 Å²
IUPAC Name: 3-[(Trimethylazaniumyl)amino]propanoate
SMILES: [O-]C(=O)CCN[N+](C)(C)C
InChI: InChI=1/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
InChIKey: PVBQYTCFVWZSJK-UHFFFAOYAX
Std. InChI: InChI=1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
Std. InChIKey: PVBQYTCFVWZSJK-UHFFFAOYSA-N
Synonyms of Meldonium (CAS NO.76144-81-5): Meldonium [INN] ; 2-(2-Carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt ; 3-(2,2,2-Trimethyldiazaniumyl)propanoate ; BRN 3938272 ; CCRIS 8536 ; Kvaterin ; Mildronate ; Quaterin ; UNII-73H7UDN6EC ; Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, hydroxide, inner salt
Classification Code: Adjuvants, immunologic ; Cardiovascular agents ; Drug / Therapeutic Agent Immunologic Factors

Mildronate Uses

Meldonium (CAS NO.76144-81-5) is used as a novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium.

Mildronate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	intraperitoneal	> 4gm/kg (4000mg/kg)		Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
mouse	LD50	intraperitoneal	7850mg/kg (7850mg/kg)		British UK Patent Application. Vol. #2105992,
mouse	LD50	intravenous	4430mg/kg (4430mg/kg)		British UK Patent Application. Vol. #2105992,
mouse	LD50	oral	18500mg/kg (18500mg/kg)		Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
rabbit	LDLo	intravenous	8gm/kg (8000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
rat	LD50	intraperitoneal	12gm/kg (12000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
rat	LD50	oral	> 20gm/kg (20000mg/kg)		Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.