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Basic information

  • Name:

  • Minoxidil

  • CAS No.:

  • 38304-91-5

  • Formula:
  • C9H15N5O
  • Synonyms:
  • Mimosine;Minoxidil(USP 24);Minoxidil USP/BP;Loniten (TN);U-10,858;2,4-Diamino-6-piperidinopyrimidine 3-N-oxide;Prexidil;6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine;Alopexil;U 10858;Regaine;Minossidile [Italian];Prestwick_521;Minoximen;2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide;Loniten;2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine;Minoxidilum [INN-Latin];Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide;Minoxidil (USP);PDP;Tricoxidil;6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide;2,6-Diamino-4-piperidinopyrimidin-1-oxid;Rogaine;Alostil;3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine;6-Piperidino-2,4-diaminopyrimidine 3-oxide;2,4-Pyrimidinediamine,6-(1-piperidinyl)-,3- oxide;2,4-Diamino-6-piperidinopyrimidine 3-oxide;2,4-Diamino-6-piperidinilpirimidina-3-ossido [Italian];Theroxidil;4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-;

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Chemistry


IUPAC Name: 3-Hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
Molecular Formula: C9H15N5O 
Molecular Weight: 209.251 g/mol
EINECS: 253-874-2 
Index of Refraction: 1.723
Density: 1.52 g/cm3
Flash Point: 166.5 °C
Melting point: 272-274 °C (dec.)(lit.)
Appearance: White crystalline solid
Enthalpy of Vaporization: 69.06 kJ/mol
Boiling Point: 351.7 °C at 760 mmHg
Vapour Pressure: 2.38E-06 mmHg at 25 °C
Product Category of Minoxidil (CAS NO.38304-91-5): Intermediates & Fine Chemicals;Pharmaceuticals;API's;Potassium channel

Uses

 Minoxidil (CAS NO.38304-91-5) can slow or stop hair loss and promote hair regrowth, so it is used for treatment of androgenic alopecia, among other baldness treatments. It was first used by  to treat high blood pressure.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 69mg/kg/34W-I (69mg/kg) CARDIAC: PERICARDITIS
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)		 Western Journal of Medicine. Vol. 143, Pg. 527, 1985.
man TDLo oral 107ug/kg/3D-I (0.107mg/kg) BLOOD: THROMBOCYTOPENIA Annals of Internal Medicine. Vol. 92, Pg. 874, 1980.
mouse LD50 intraperitoneal 560mg/kg (560mg/kg)   Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982.
mouse LD50 intravenous 51mg/kg (51mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982.
rat LD50 intraperitoneal 759mg/kg (759mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
rat LD50 intravenous 49mg/kg (49mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
rat LD50 oral 1321mg/kg (1321mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
women TDLo oral 200ug/kg (0.2mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
GASTROINTESTINAL: NAUSEA OR VOMITING		 Archives of Internal Medicine. Vol. 146, Pg. 2075, 1986.
 

Safety Profile

Hazard Codes: HarmfulXn,VeryT+
Risk Statements: 22-36/37/38-26/27/28 
R22:Harmful if swallowed. 
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-45-36/37/39-22 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Specification

 Minoxidil , its cas register number is 38304-91-5. It also can be called 6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide ; Loniten ; Regain ; Rogaine ; and 2,4-Diamino-6-piperidino-pyrimidine-3-oxide . In 2007 a new foam-based formulation of 5% minoxidil was shown to be as effective as the liquid-based treatment for male pattern baldness.

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