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Basic information

  • Name:
  • Morpholine

  • CAS No.:
  • 110-91-8

  • Formula:
  • C4H9NO
  • Synonyms:
  • Diethylenimide oxide;Drewamine;BASF 238;1-Oxa-4-azacyclohexane;Tetrahydro-2H-1,4-oxazine;Morpholine (4-oxazine);Tetrahydro-p-oxazine;Diethyleneimide oxide;Diethylene oximide;Tetrahydro-1,4-oxazine;2H-1,4-Oxazine, tetrahydro-;Morpholine hydrochloride;p-Isoxazine, tetrahydro-;Diethylene imidoxide;Tetrahydro-1, 4-isoxazine;1-oxa-4-azoniacyclohexane;4H-1,4-Oxazine, tetrahydro-;
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Chemistry

Molecular structure of Morpholine (CAS NO.110-91-8) is:

Product Name: Morpholine
CAS Registry Number: 110-91-8
IUPAC Name: morpholine
Molecular Weight: 87.12036 [g/mol]
Molecular Formula: C4H9NO
XLogP3: -0.9
H-Bond Donor: 1
H-Bond Acceptor: 2 
EINECS: 203-815-1
Melting Point: -5 °C
Refractive index: n20/D 1.454(lit.)
Storage temp.: Store at R.T.
Water Solubility: MISCIBLE 
Sensitive: Hygroscopic
Surface Tension: 29.2 dyne/cm
Density: 0.931 g/cm3
Flash Point: 35.6 °C
Enthalpy of Vaporization: 36.66 kJ/mol
Boiling Point: 128.9 °C at 760 mmHg
Vapour Pressure: 10.4 mmHg at 25°C
Product Categories: Organic Chemicals;BasesChemical Synthesis;Organic Bases;Supported Reagents;Supported Synthesis;Synthetic Reagents

Uses

 Morpholine (CAS NO.110-91-8) is a common additive because its volatility is about the same as water. Morpholine is often used in conjunction with low concentrations of hydrazine or ammonia to provide a comprehensive all-volatile treatment chemistry for corrosion protection for the steam systems of such plants.

Production

 Morpholine (CAS NO.110-91-8) may be produced by the dehydration of diethanolamine with sulfuric acid.
 

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo oral 100mg/kg (100mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 236, 1939.
mammal (species unspecified) LC50 inhalation 12000mg/m3 (12000mg/m3)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mammal (species unspecified) LD50 oral 1220mg/kg (1220mg/kg)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mouse LC50 inhalation 1320mg/m3/2H (1320mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 60, 1966.
mouse LD50 intraperitoneal 413mg/kg (413mg/kg)   Cancer Vol. 2, Pg. 1055, 1949.
mouse LD50 oral 525mg/kg (525mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985.
mouse LD50 subcutaneous 458mg/kg (458mg/kg)   United States Patent Document. Vol. #4576951,
rabbit LD50 skin 500uL/kg (0.5mL/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat LC50 inhalation 8000ppm/8H (8000ppm)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 85, 1974.
rat LD50 oral 1450mg/kg (1450mg/kg)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968.
rat LDLo unreported 1600mg/kg (1600mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 662, 1969.

Safety Profile

Moderately toxic by ingestion, inhalation, skin contact, and intraperitoneal routes. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Can cause kidney damage. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid. A very dangerous fire hazard when exposed to flame, heat, or oxidizers; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. Mixtures with nitromethane are explosive. May ignite spontaneously in contact with cellulose nitrate of high surface area. When heated to decomposition it emits highly toxic fumes of NOx
Hazard Codes: CorrosiveC
Risk Statements: 10-20/21/22-34 
R10:Flammable. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R34:Causes burns.
Safety Statements: 23-36-45 
S23:Do not breathe vapour. 
S36:Wear suitable protective clothing. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2054 8/PG 1
WGK Germany: 3
RTECS: QD6475000
HazardClass: 8
PackingGroup: I

Specification

 Morpholine , its cas register number is 110-91-8. It also can be called Tetrahydro-1,4-oxazine ; 1-Oxa-4-azacyclohexane ; 2H-1,4-Oxazine, tetrahydro- ; 4H-1,4-Oxazine, tetrahydro- ; Diethylene imidoxide ; Diethylene oximide ; Tetrahydro-1,4-isoxazine ; Tetrahydro-1,4-oxazine ; Tetrahydro-p-oxazine ; p-Isoxazine, tetrahydro- .It is a aqueous solution with a fishlike odor.It is highly flammable and water soluble.It dissolved in water neutralizes acids in exothermic reactions to form salts plus water. It may cause toxic effects if inhaled or ingested/swallowed. Morpholine decomposes reasonably slowly in the absence of oxygen even at the high temperatures and pressures in these steam systems.

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