N-(3-Chloropropyl)morpholine (7357-67-7),N-(3-Chloropropyl)morpholine (7357-67-7) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
N-(3-Chloropropyl)morpholine
CAS No.:
7357-67-7
Molecular Structure:
Formula:
C₇H₁₄ClNO
Molecular Weight:
163.65
Synonyms:
1-Chloro-3-morpholinopropane;3-(Morpholin-4-yl)propyl chloride;3-Chloro-1-(morpholin-4-yl)propane;3-Morpholinopropyl chloride;4-(3-Chloropropyl)morpholine;Morpholine,4-(3-chloropropyl)-;
Density:
1.062 g/cm³
Boiling Point:
227.1 °C at 760 mmHg
Flash Point:
91.2 °C
Risk Codes:
36/37/38
Safety Description:
26-36/37/39 Details

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Chemistry

IUPAC Name: 4-(3-Chloropropyl)morpholine
Molecular Formula: C₇H₁₄ClNO
Molecular Weight: 163.64 g/mol
SMILES: N1(CCCCl)CCOCC1
InChI: InChI=1/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
Product Categories: Aromatic Morpholines; Benzomorpholines & Benzothiomorpholines; Methyl Halides;Morpholines & Thiomorpholines; API intermediates; Heterocycles; Intermediates; Intermediates & Fine Chemicals; Pharmaceuticals; Benzomorpholines & Benzothiomorpholines; Methyl Halides; Morpholines & Thiomorpholines
Index of Refraction: 1.463
Molar Refractivity: 42.42 cm³
Molar Volume: 154 cm³
Polarizability: 16.81×10^-24 cm³
Surface Tension: 32 dyne/cm
Density: 1.062 g/cm³
Flash Point: 91.2 °C
Enthalpy of Vaporization: 46.37 kJ/mol
Boiling Point: 227.1 °C at 760 mmHg
Vapour Pressure of N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7): 0.0789 mmHg at 25 °C

Uses

N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7) is commonly used as gefitinib intermediate.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	104mg/kg (104mg/kg)		Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 33, Pg. 169, 1976.

Safety Profile

Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements of N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7): 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Specification

N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7), its Synonyms are 1-Chloro-3-morpholinopropane ; 3-Morpholinopropyl chloride ; 4-(3-Chloropropyl)morpholine ; Morpholine, 4-(3-chloropropyl)- .