Methionine,N-acetyl-

The IUPAC name of N-Acetyl-DL-methionine is 2-acetamido-4-methylsulfanylbutanoic acid. With the CAS registry number 1115-47-5, it is also named as Methionamine. The product's categories are Amino Acids; Methionine [Met, M]; Ac-Amino Acids; Amino Acids (N-Protected); Biochemistry; Pharmaceutical Intermediates, and the other registry number is 25129-27-5. Besides, it is white crystalline powder, which should be stored in closed containers in a cool, dry place at 0-6 °C. In addition, its molecular formula is C₇H₁₃NO₃S and molecular weight is 191.24.

The other characteristics of this product can be summarized as: (1)EINECS: 214-224-3; (2)ACD/LogP: -0.19; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -2.48; (5)ACD/LogD (pH 7.4): -3.81; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 4; (11)#H bond donors: 2; (12)#Freely Rotating Bonds: 5; (13)Index of Refraction: 1.51; (14)Molar Refractivity: 47.62 cm³; (15)Molar Volume: 158.9 cm³; (16)Surface Tension: 45.7 dyne/cm; (17)Density: 1.202 g/cm³; (18)Flash Point: 228.1 °C; (19)Melting point: 117-119 °C; (20)Enthalpy of Vaporization: 78.15 kJ/mol; (21)Boiling Point: 453.6 °C at 760 mmHg; (22)Vapour Pressure: 1.72E-09 mmHg at 25 °C.

Preparation of N-Acetyl-DL-methionine: this chemical can be prepared by the reaction of 3-methylsulfanyl-propionaldehyde and acetamide with carbon monoxide.



This reaction needs H₂SO₄, LiBr, (PPh₃)₂PdBr₂ at temperature of 120 °C. The reaction time is 12 hours. The yield is 75 %.

Uses of N-Acetyl-DL-methionine: it can react with 5,6-diamino-1,3-dimethyl-1H-pyrimidine-2,4-dione to get 2-acetylamino-N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-methylsulfanyl-butyramide.



This reaction needs o-xylene by heating for 4 hours. The yield is 61 %.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(NC(C(=O)O)CCSC)C
(2)InChI: InChI=1/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)
(3)InChIKey: XUYPXLNMDZIRQH-UHFFFAOYAQ

The toxicity data is as follows: