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Cas Database |
| Name |
N-Cbz-N'-Boc-L-lysine dicyclohexylamine |
EINECS | 218-663-1 |
| CAS No. | 2212-76-2 | Density | N/A |
| PSA | 125.99000 | LogP | 7.47510 |
| Solubility | N/A | Melting Point |
154-156 °C |
| Formula | C19H28N2O6.C12H23N | Boiling Point | 587 °C at 760 mmHg |
| Molecular Weight | 561.762 | Flash Point | 308.8 °C |
| Transport Information | N/A | Appearance | white crystals |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
N2-((Benzyloxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysine, compound with dicyclohexylamine (1:1);N-cyclohexylcyclohexanamine; (2S)-2-phenylmethoxycarbonylamino-6-(tert-butoxycarbonylamino)hexanoic acid;Z-LYS(BOC)-OH DCHA;N-α-Z-N-ε-Boc-L-lysine dicyclohexylamine salt;Z-Lys(Boc)-OH.DCHA;Cbz-Lys(Boc)-OH·DCHA;Z-Lys(Boc)-OH·DCHA; |
Article Data | 3 |
N-Cbz-N'-Boc-L-lysine dicyclohexylamine Synthetic route
- 19506-72-0
benzyl-8-quinolyl carbonate
- 24424-99-5
di-tert-butyl dicarbonate
- 657-27-2, 10098-89-2
L-Lysine hydrochloride
- 101-83-7
N-cyclohexyl-cyclohexanamine
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
| Conditions | Yield |
|---|---|
| Multistep reaction; | 91% |
- 2389-60-8
Z-Lys(Boc)-OH
- 101-83-7
N-cyclohexyl-cyclohexanamine
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
| Conditions | Yield |
|---|---|
| In Isopropyl acetate |
- 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 3338-34-9
Z-Lys(-Boc)-Osu
| Conditions | Yield |
|---|---|
| With dicyclohexyl-carbodiimide In dichloromethane at 0℃; | 98% |
| Stage #1: Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt With sulfuric acid In ethyl acetate for 0.5h; Stage #2: 1-hydroxy-pyrrolidine-2,5-dione With dicyclohexyl-carbodiimide In ethyl acetate at 20℃; for 20h; | 95% |
- 5680-79-5
glycine ethyl ester hydrochloride
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 10342-52-6
Nα-Benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysylglycine Methyl Ester
| Conditions | Yield |
|---|---|
| With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0 - 25℃; | 90% |
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 122-80-5
N-acetyl-p-phenylenediamine
- 139009-82-8
N2-(benzyloxycarbonyl)-N6-(tert-butoxycarbonyl)-L-lysin-4-acetamidoanilide
| Conditions | Yield |
|---|---|
| With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide 1) 0-5 deg C, 1 h, 2) room temperature, 4 h; | 72% |
- 186581-53-3, 908094-01-9
diazomethane
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 2389-49-3
Nα-(benzyloxycarbonyl)-Nε-(tert-butoxycarbonyl)-L-lysine methyl ester
| Conditions | Yield |
|---|---|
| (i) ion-exchange resin + form>, EtOH, (ii) /BRN= 102415/, Et2O; Multistep reaction; |
- 2491-20-5
L-alanine methyl ester hydrochloride
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 50466-60-9
Cbz-Lys(Boc)-Ala-OMe
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine; chloroformic acid ethyl ester 1.) THF, -15 deg C, 2.) H2O, THF, -15 deg to r.t., 45 h; Yield given. Multistep reaction; |
- 53518-15-3
Coumarin 151
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 73496-37-4
7-(Nα-Z-Nε-Boc-L-Lysinamido)-4-(trifluoromethyl)-coumarin
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine; toluene-4-sulfonic acid; isobutyl chloroformate Yield given. Multistep reaction; |
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 110-58-7
1-pentanamine
- 159360-26-6
N2-(benzyloxycarbonyl)-N6-<(tert-butoxy)carbonyl>-N1-pentyllysinamid
| Conditions | Yield |
|---|---|
| Yield given. Multistep reaction; |
- 25887-81-4
bis(p-nitrophenyl)sulfite
- 2212-76-2
Nα-benzyloxycarbonyl-Nε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
- 2212-69-3
N2-benzyloxycarbonyl-N6-t-butoxycarbonyl-L-lysine 4-nitrophenyl ester
| Conditions | Yield |
|---|---|
| (i) aq. citric acid, Et2O, (ii) /BRN= 1893948/, Py; Multistep reaction; |
N-Cbz-N'-Boc-L-lysine dicyclohexylamine Specification
The IUPAC name of Z-Lys(Boc)-OH DCHA is N-cyclohexylcyclohexanamine; (2S)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoic acid . With the CAS registry number 2212-76-2, it is also named as N2-((Benzyloxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysine, compound with dicyclohexylamine (1:1) ; (2S)-2-{[(Benzyloxy)carbonyl]amino}-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)hexanoic acid - N-cyclohexylcyclohexanamine (1:1) ; L-lysine, N~6~-[(1,1-dimethylethoxy)carbonyl]-N~2~-[(phenylmethoxy)carbonyl]-, compd. with N-cyclohexylcyclohexanamine (1:1) .
The Z-Lys(Boc)-OH DCHA is white crystals which should be stored at the temperature of 2-8°C. It can be used as pharmaceutical intermediates. The product's categories are Z-amino acids and derivatives.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.14 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 1.18 ; (4)ACD/LogD (pH 7.4): -0.36 ; (5)ACD/BCF (pH 5.5): 1.57 ; (6)ACD/BCF (pH 7.4): 1 ; (7)ACD/KOC (pH 5.5): 13.34 ; (8)ACD/KOC (pH 7.4): 1 ; (9)#H bond acceptors: 8 ; (10)#H bond donors: 3 ; (11)#Freely Rotating Bonds: 12 ; (12)Enthalpy of Vaporization: 92.2 kJ/mol ; (13)Vapour Pressure: 1.26E-14 mmHg at 25°C ; (14)Rotatable Bond Count: 14 ; (15)Tautomer Count: 4 ; (16)Exact Mass: 561.377786 ; (17)MonoIsotopic Mass: 561.377786 ; (18)Topological Polar Surface Area: 126 ; (19)Heavy Atom Count: 40 ; (20)Complexity: 599.
People can use the following data to convert to the molecule structure. SMILES: O=C(OC(C)(C)C)NCCCC[C@@H](C(=O)O)NC(=O)OCc1ccccc1.N(C1CCCCC1)C2CCCCC2; InChI: InChI=1/C19H28N2O6.C12H23N/c1-19(2,3)27-17(24)20-12-8-7-11-15(16(22)23)21-18(25)26-13-14-9-5-4-6-10-14;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h4-6,9-10,15H,7-8,11-13H2,1-3H3,(H,20,24)(H,21,25)(H,22,23);11-13H,1-10H2/t15-;/m0./s1.
The Z-Lys(Boc)-OH DCHA has many suppliers, such as GL Biochem (Shanghai) Ltd., Chengdu Chengnuo New-Tech Co., Ltd., Shanghai Xianchong Chemical Co., Ltd., Sichuan Emei Ronggao Biochemicals Co., Ltd., Sichuan Sangao Biochemical Co., Ltd. and Sinfachem Limited.
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