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| Name |
N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride |
EINECS | N/A |
| CAS No. | 2240-14-4 | Density | N/A |
| PSA | 12.03000 | LogP | 4.37110 |
| Solubility | N/A | Melting Point |
192° |
| Formula | C15H21 N . Cl H | Boiling Point | 322.8°C at 760 mmHg |
| Molecular Weight | 251.83 | Flash Point | 152.9°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, subcutaneous, and intravenous routes. A central nervous system stimulant. When heated to decomposition it emits very toxic fumes of HCl and NOx. | Risk Codes | 11-23/24/25-39/23/24/25 |
| Molecular Structure |
|
Hazard Symbols | F,T |
| Synonyms |
2-Norbornanamine,N-ethyl-3-phenyl-, hydrochloride (7CI,8CI); Bicyclo[2.2.1]heptan-2-amine,N-ethyl-3-phenyl-, hydrochloride (9CI);2-Ethylamino-3-phenylbicyclo[2.2.1]heptane hydrochloride;2-Ethylamino-3-phenylnorcamphane hydrochloride; Fencamfamin hydrochloride;Fencamfamine hydrochloride; H 610; N-Ethyl-3-phenyl-2-norbornylamine hydrochloride;Sicoclor |
N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride Chemical Properties
Chemistry informtion about N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride (CAS NO.2240-14-4) is:
IUPAC Name: N-Ethyl-6-Phenylbicyclo[2.2.1]Heptan-5-Amine Hydrochloride
Synonyms: Fencamfamine Hydrochloride, Drug Standar D Solution ; 2-Aethylamino-3-Phenyl-Nor-Camphanhydrochlorid ; 2-Ethylamino-3-Phenyl-Norcamphanehydrochloride ; Fencamfaminehydrochloride ; N-Ethyl-3-Phenyl-2-Norbornanaminhydrochloride ; Fencamfamin Hydrochloride ; N-Ethyl-3-Phenyl-Norbornan-2-Amine
MF: C15H21N
MW: 215.33394
EINECS: 218-805-2
Density: 1.02 g/cm3
Flash Point: 152.9 °C
Boiling Point: 322.8 °C at 760 mmHg
Vapour Pressure: 0.000273 mmHg at 25°C
Enthalpy of Vaporization: 56.47 kJ/mol
Following is the molecular structure of N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride (CAS NO.2240-14-4) is:
N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 34mg/kg (34mg/kg) | behavioral: tremor behavioral: convulsions or effect on seizure threshold behavioral: excitement | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
| dog | LD50 | intravenous | 15mg/kg (15mg/kg) | behavioral: excitement behavioral: ataxia cardiac: pulse rate increase without fall in bp | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
| dog | LD50 | oral | 30mg/kg (30mg/kg) | behavioral: excitement behavioral: ataxia cardiac: pulse rate increase without fall in bp | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
| mouse | LD50 | intravenous | 15700ug/kg (15.7mg/kg) | peripheral nerve and sensation: spastic paralysis with or without sensory change behavioral: convulsions or effect on seizure threshold behavioral: excitement | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
| mouse | LD50 | oral | 135mg/kg (135mg/kg) | peripheral nerve and sensation: spastic paralysis with or without sensory change behavioral: convulsions or effect on seizure threshold behavioral: excitement | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
| mouse | LD50 | subcutaneous | 85500ug/kg (85.5mg/kg) | peripheral nerve and sensation: spastic paralysis with or without sensory change behavioral: excitement behavioral: convulsions or effect on seizure threshold | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
| rat | LD50 | intravenous | 23500ug/kg (23.5mg/kg) | peripheral nerve and sensation: spastic paralysis with or without sensory change behavioral: convulsions or effect on seizure threshold behavioral: excitement | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
| rat | LD50 | oral | 83mg/kg (83mg/kg) | Journal of Pediatrics. Vol. 69, Pg. 663, 1966. | |
| rat | LD50 | subcutaneous | 68500ug/kg (68.5mg/kg) | peripheral nerve and sensation: spastic paralysis with or without sensory change behavioral: convulsions or effect on seizure threshold behavioral: excitement | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 20, 1961. |
N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. A central nervous system stimulant. When heated to decomposition it emits very toxic fumes of HCl and NOx.
N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride Specification
N-Ethyl-3-Phenyl-2-Norbornanamine Hydrochloride (CAS NO.2240-14-4) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dextroamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases.Reactivan tablets; Reactivan syrup Fencamfamine acts as an indirect dopamine agonist. It releases dopamine by a similar mechanism to amphetamines, but is ten times less potent than dexamphetamine at producing this effect. The main mechanism of action is instead inhibition of dopamine reuptake, more similar to that of methylphenidate. Also unlike amphetamines, fencamfamine does not inhibit the action of monoamine oxidase enzymes and so is somewhat safer. Some experiments also suggest a role for opioid receptors in the activity of fencamfamine, as low doses can cause paradoxical sedation, and some effects of the drug are blocked by naloxone.
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