Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	N-Methyl-4-chloropyridine-2-carboxamide	EINECS	606-888-1
CAS No.	220000-87-3	Density	1.264 g/cm³
PSA	41.99000	LogP	1.48550
Solubility	N/A	Melting Point	41-43 °C
Formula	C₇H₇ClN₂O	Boiling Point	317.8 °C at 760 mmHg
Molecular Weight	170.598	Flash Point	146 °C
Transport Information	N/A	Appearance	pale-yellow solid
Safety	26	Risk Codes	22-36
Molecular Structure		Hazard Symbols	Xn
Synonyms	2-(N-Methylcarbamoyl)-4-chloropyridine;4-Chloro-N-methyl-2-pyridinecarboxamide;4-Chloropyridine-2-carboxylicacid methylamide;N-Methyl-4-chloropicolinamide;	Article Data	105

N-Methyl-4-chloropyridine-2-carboxamide Synthetic route

: 24484-93-3
4-Chloro-pyridine-2-carboxylic acid methyl ester

: 74-89-5
methylamine

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
With magnesium chloride In tetrahydrofuran at 20℃; for 2.25h;	98.5%
In methanol at 0 - 5℃; for 2h;	98%
magnesium chloride In tetrahydrofuran at 20℃; for 2.25h;	98.5%

: 74-89-5
methylamine

: methyl 4-chloropyridine-2-carboxylate hydrochloride

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 10℃; for 6h; Temperature; Solvent;	98%
In tetrahydrofuran; methanol at 0 - 5℃; for 5h; Product distribution / selectivity;	97%
In tetrahydrofuran; methanol at 0 - 5℃; Inert atmosphere;	97%

: methyl 4-chloropyridine-2-carboxylate hydrochloride

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
With methylamine In tetrahydrofuran; methanol; ethyl acetate	97%
With methylamine In tetrahydrofuran; methanol; ethyl acetate	97%
With methylamine In tetrahydrofuran; methanol; ethyl acetate	97%
With methylamine In tetrahydrofuran; methanol; ethyl acetate	97%
With methylamine In tetrahydrofuran; methanol at 0 - 3℃; for 4h;

: methyl 4-chloropyridine-2-carboxylate hydrochloride

A of4-chloro-N-methyl-2-pyridinecarboxamide: of4-chloro-N-methyl-2-pyridinecarboxamide

B: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
With methylamine In tetrahydrofuran; methanol; ethyl acetate	A 97% B n/a

: 4-chloro-2-pyridine carboxylic acid chloride hydrochloride

: 74-89-5
methylamine

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere;	94%
With sodium hydroxide In tetrahydrofuran at -5℃; for 3h; Temperature; Solvent;	93%
In tetrahydrofuran; methanol at 0 - 3℃; for 4h; Product distribution / selectivity;	88%

: 63071-13-6
4-chloro-2-pyridinecarbaldehyde

: 74-89-5
methylamine

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
In methanol at 0 - 25℃; for 6h;	82.1%

: 74-89-5
methylamine

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
Stage #1: methyl 4-chloropyridine-2-carboxylate hydrochloride With magnesium chloride In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: methylamine at 20℃; for 16.3333h;	81%
Stage #1: methyl 4-chloropyridine-2-carboxylate hydrochloride With magnesium chloride In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: methylamine In tetrahydrofuran at 20℃; for 16.33h;	81%

: 53750-66-6
4-chloro-pyridine-2-carbonyl chloride

: 74-89-5
methylamine

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 3.5h;	81%
In dichloromethane at 0 - 20℃; for 3h;	81%
With triethylamine In tetrahydrofuran; water for 3h; Cooling with ice;	78%

: 5470-22-4
4-chloropicolinic acid

: 74-89-5
methylamine

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
Stage #1: 4-chloropicolinic acid With thionyl chloride at 80℃; for 3h; Stage #2: methylamine With triethylamine In dichloromethane at 20 - 27℃; for 2h;	46%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 48h;	22%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 3h;
With hydrogenchloride In ethanol; water at 120℃; for 4h; Solvent; Temperature;	15.2 g

: 98-98-6
2-Picolinic acid

: 74-89-5
methylamine

: 220000-87-3
4-chloro-N-methylpicolinamide

Conditions

Conditions	Yield
Stage #1: 2-Picolinic acid With thionyl chloride In N,N-dimethyl-formamide at 45 - 72℃; for 72h; Stage #2: methylamine In tetrahydrofuran; water at 0 - 20℃; for 4h; Temperature;	39%
Stage #1: 2-Picolinic acid With thionyl chloride In N,N-dimethyl-formamide Stage #2: methylamine
Stage #1: 2-Picolinic acid With thionyl chloride; N,N-dimethyl-formamide at 45 - 75℃; for 72h; Stage #2: methylamine In tetrahydrofuran; water at 0 - 25℃; for 4h;

N-Methyl-4-chloropyridine-2-carboxamide Chemical Properties

Product Name: N-Methyl-4-chloropyridine-2-carboxamide
Molecular Structure of N-Methyl-4-chloropyridine-2-carboxamide (CAS NO.220000-87-3):

Molecular Formula: C₇H₇ClN₂O
Molecular Weight: 170.5963
Synonyms of N-Methyl-4-chloropyridine-2-carboxamide (CAS NO.220000-87-3): 4-Chloropyridine-2-carboxylic acid methylamide ; N-Methyl-4-chloro-2-pyridinecarboxamide
CAS NO: 220000-87-3
Classification Code: blocks ; Carboxes ; Pyridines ; Pyridine ; Amines ; Aromatics ; Heterocycles
Melting Point: 41-43°C
Index of Refraction: 1.547
Molar Refractivity: 42.86 cm³
Molar Volume: 134.9 cm³
Surface Tension: 45.4 dyne/cm
Density: 1.264 g/cm³
Flash Point: 146 °C
Enthalpy of Vaporization: 55.93 kJ/mol
Boiling Point: 317.8 °C at 760 mmHg
Vapour Pressure of N-Methyl-4-chloropyridine-2-carboxamide (CAS NO.220000-87-3): 0.000375 mmHg at 25°C

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 220000-87-3