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N-Methyl-N-nitrosotoluene-4-sulphonamide
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Name

N-Methyl-N-nitrosotoluene-4-sulphonamide

 EINECS 201-252-6
CAS No. 80-11-5 Density 1.3 g/cm3
PSA 75.19000 LogP 2.37770
Solubility N/A Melting Point ~58 °C
Formula C8H10N2O3S Boiling Point 320.5 °C at 760 mmHg
Molecular Weight 214.245 Flash Point 147.6 °C
Transport Information UN 3234 4.1/PG 2 Appearance pale yellow crystalline powder
Safety 15-26-35-36/37-36 Risk Codes 2-36/37/38-43-20/21/22
Molecular Structure Molecular Structure of 80-11-5 (N-Methyl-N-nitrosotoluene-4-sulphonamide) Hazard Symbols ExplosiveE,IrritantXi,HarmfulXn
Synonyms

p-Toluenesulfonamide,N-methyl-N-nitroso- (6CI,7CI,8CI);Diazald;Diazale;N-Methyl-N-nitroso-4-tosylamide;N-Nitroso-N-methyl-p-toluenesulfonamide;NSC 313;p-Tolylsulfonylmethylnitrosamide;

Article Data 18

N-Methyl-N-nitrosotoluene-4-sulphonamide Synthetic route

640-61-9

N-methyl-p-toluenesulfonylamide

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

Conditions
ConditionsYield
With hydrogenchloride; water; sodium nitrite In diethyl ether81%
With perchloric acid; sodium nitrite In dichloromethane; water Rate constant; Equilibrium constant; nitrosation of substituted N-methylbenzenesulfonamides; reversibility; kinetics of nitrosation and denitrosation; substituent effect; acid catalysis; effect of nucleophiles; mechanism;
With dinitrogen tetraoxide
98-59-9

p-toluenesulfonyl chloride

74-89-5

methylamine

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

Conditions
ConditionsYield
With sodium hydroxide Behandeln des Reaktionsgemisches mit Essigsaeure und NaNO2;
67764-33-4

cyclopentyl nitrite

640-61-9

N-methyl-p-toluenesulfonylamide

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

Conditions
ConditionsYield
With diluted acid
22547-51-9

1-methyl-1-(4-tolylsulfonyl)hydrazine

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

Conditions
ConditionsYield
With trifluoroacetic acid; sodium nitrite
98-59-9

p-toluenesulfonyl chloride

3058-37-5

(Z)-potassium methanediazotate

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

Conditions
ConditionsYield
In diethyl ether
103999-21-9

C8H10NO2S(1-)

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

Conditions
ConditionsYield
With nitrosonium perchlorate In acetonitrile at 25℃; Thermodynamic data;

N-methyl-N-(t-butoxycarbonyl)-p-toluenesulfonamide

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / neat (no solvent) / 1 h / 0 - 23 °C
2: sodium chloride; sodium acetate; sodium nitrite; acetic acid / water / 0.25 h / 0 °C
View Scheme
80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

640-61-9

N-methyl-p-toluenesulfonylamide

Conditions
ConditionsYield
With sulfite(2-) In 1,4-dioxane; water at 25℃; Rate constant;100%
With Thiocyanate In 1,4-dioxane; water at 25℃; Rate constant;100%
With thiourea In 1,4-dioxane; water at 25℃; Rate constant;100%
80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

47173-80-8

N-Boc-D-serine(Bzl)-OH

67389-47-3

(R)-3-benzyloxy-2-tert-butoxycarbonyl-amino-propionic acid methyl ester

Conditions
ConditionsYield
99%
2941-78-8

2-Amino-5-methylbenzoic acid

80-11-5

N-methyl-N-nitrosotoluene-p-sulfonamide

18595-16-9

2-amino-5-methylbenzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: N-methyl-N-nitrosotoluene-p-sulfonamide With potassium hydroxide In diethyl ether; water
Stage #2: 2-Amino-5-methylbenzoic acid In diethyl ether for 1h;		99%

N-Methyl-N-nitrosotoluene-4-sulphonamide Chemical Properties

Molecular Formula: C8H10N2O3S
Molecular Weight: 214.24
EINECS: 201-252-6
Density: 1.3 g/cm3 
Flash Point: 147.6 °C
Storage temp: 2-8°C
Index of Refraction: 1.572  
Enthalpy of Vaporization: 56.22 kJ/mol 
Boiling Point: 320.5 °C at 760 mmHg 
Vapour Pressure: 0.000317 mmHg at 25°C
Appearance: pale yellow crystalline powder
Product Categories: Pharmaceutical Intermediates
Stability: Stable, but heat sensitive; may also be light sensitive. Incompatible with strong oxidizing agents, alkalies.
Synonyms: Benzenesulfonamide, N,4-dimethyl-N-nitroso- ; Benzenesulfonamide,N,4-dimethyl-N-nitroso- ; Diazale;diazalo ; Methylnitroso-p-toluenesulfonamide ; N,4-dimethyl-n-nitroso-benzenesulfonamid ; N,4-dimethyl-N-nitroso-Benzenesulfonamide ; N,4-Dimethyl-N'-oxobenzenesulfonohydrazide
Following is the molecular structure of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):

N-Methyl-N-nitrosotoluene-4-sulphonamide Toxicity Data With Reference

 The toxicity of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 19mg/kg (19mg/kg)   Cancer Research. Vol. 30, Pg. 11, 1970.
rat LD50 oral 2700mg/kg (2700mg/kg)   Naturwissenschaften. Vol. 48, Pg. 165, 1961.

N-Methyl-N-nitrosotoluene-4-sulphonamide Safety Profile

Safety Information of N-Methyl-N-Nitroso-P-Toluene Sulfonamide (80-11-5):
Hazard Codes: E,Xi,Xn 
E: Explosive Xn: Harmful Xi: Irritant
Risk Statements: 2-36/37/38-43-20/21/22
2: Risk of explosion by shock, friction, fire or other sources of ignition
36/37/38: Irritating to eyes, respiratory system and skin 
43: May cause sensitization by skin contact 
20/21/22: Harmful by inhalation, in contact with skin and if swallowed 
Safety Statements: 15-26-35-36/37-36
15: Keep away from heat 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
35:  This material and its container must be disposed of in a safe way 
36/37: Wear suitable protective clothing and gloves 
36: Wear suitable protective clothing 
RIDADR:  UN 3234 4.1/PG 2
WGK Germany: 2
RTECS: XT5950000
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 80-11-5(Hazardous Substances Data)
 

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