Basic information
- Name:
1,2-Ethanediamine,N1,N1,N2,N2-tetramethyl-
- Superlist Name:
- N,N,N',N'-Tetramethylethylenediamine
- CAS No.:
110-18-9
- Molecular Structure:
- Formula:
- C6H16N2
- Molecular Weight:
- 116.24
- Synonyms:
- 1,2-Ethanediamine,N,N,N',N'-tetramethyl- (9CI);Ethylenediamine, N,N,N',N'-tetramethyl-(6CI,8CI);(2-(Dimethylamino)ethyl)dimethylamine;1,2-Bis(dimethylamino)ethane;2,5-Dimethyl-2,5-diazahexane;Dabco TMEDA;Dimethyl[2-(dimethylamino)ethyl]amine;Kaolizer 11;MR;MR (amine);N,N,N',N'-Tetramethyl-1,2-diaminoethane;N,N,N',N'-Tetramethyl-1,2-ethanediamine;N,N,N',N'-Tetramethyl-1,2-ethylenediamine;Propamine D;TEMED;TMED;TMEDA;Tetrameen;Toyocat TE;
- EINECS:
- 203-744-6
- Density:
- 0.817 g/cm3
- Melting Point:
- -55 °C(lit.)
- Boiling Point:
- 121 °C at 760 mmHg
- Flash Point:
- 10 °C
- Solubility:
- miscible with water
- Appearance:
- Colorless to slightly yellow liquid
- Hazard Symbols:
F,
C- Risk Codes:
- 11-20/22-34-20/21/22
- Safety Description:
- 16-26-36/37/39-45 Details
- Transport Information:
- UN 2372 3/PG 2
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Chemistry
Molecular formula: C6H16N2
Molar mass: 116.24 g/mol
EINECS: 203-744-6
Index of Refraction: 1.437
Density: 0.817 g/cm3
Flash Point: 10 °C
Sensitive: Hygroscopic
Melting point: -55 °C(lit.)
Storage tempreture: Store at RT.
Water solubility: Miscible
Enthalpy of Vaporization: 35.91 kJ/mol
Boiling Point: 121 °C at 760 mmHg
Vapour Pressure: 14.9 mmHg at 25 °C
Solubility: H2O: 10 mg/mL at 20 °C, clear, colorless
Appearance: Colorless to slightly yellow liquid
Structure of N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9):
Product Category of N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9): Biochemistry;Reagents for Electrophoresis
Uses
N,N,N',N'-Tetramethylethylenediamine (CAS NO.110-18-9) is widely used as a ligand for metal ions. It is used with ammonium persulfate to catalyze the polymerization of acrylamide when making polyacrylamide gels, and can be used in gel electrophoresis for the separation of proteins or nucleic acids.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 630mg/kg (630mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984. | |
| quail | LD50 | oral | > 316mg/kg (316mg/kg) | Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. | |
| rabbit | LD50 | skin | 5390mg/kg (5390mg/kg) | American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. | |
| rabbit | LD50 | subcutaneous | 1230mg/kg (1230mg/kg) | Toxicologist. Vol. 15, Pg. 19, 1995. | |
| rat | LC50 | inhalation | 1318ppm/4H (1318ppm) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: IRRITABILITY | Toxicologist. Vol. 8, Pg. 249, 1988. |
| rat | LD50 | oral | 268mg/kg (268mg/kg) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES SPINAL CORD: OTHER DEGENERATIVE CHANGES | Toxicologist. Vol. 15, Pg. 19, 1995. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Moderately toxic by ingestion. Mildly toxic by skin contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
Hazard Codes: 
F,
C,
Xi
Risk Statements: 11-20/22-34-20/21/22
R11:Highly flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R20/22:Harmful by inhalation and if swallowed.
R34:Causes burns.
Safety Statements: 16-26-36/37/39-45
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Standards and Recommendations
DOT Classification: 3; Label: Flammable Liquid
Specification
N,N,N',N'-Tetramethylethylenediamine , its cas register number is 110-18-9. It also can be called 1,2-Di(dimethylamino)ethane ; TMEDA ; and TEMED . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.