Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Naphazoline nitrate

Related Products

Hot Products

Basic Information Post buying leads Suppliers
Name

Naphazoline nitrate

EINECS 225-915-4
CAS No. 5144-52-5 Density N/A
PSA 90.44000 LogP 2.32390
Solubility N/A Melting Point 167-170 °C
Formula C14H14N2.HNO3 Boiling Point 440.5 °C at 760 mmHg
Molecular Weight 273.32 Flash Point 220.2 °C
Transport Information N/A Appearance COA
Safety 22-36/37 Risk Codes 22
Molecular Structure Molecular Structure of 5144-52-5 (Naphazoline nitrate) Hazard Symbols HarmfulXn
Synonyms

Naphthizen;Rino Naftazolina;Prizoliene N;Naphazoline nitrate (JP14);Benil;Minha;Sanorin;Clera;Privine (British);Vistalbalon;Naphthisin;Imizol;Proculin;1H-Imidazole,4,5-dihydro-2-(1-naphthalenylmethyl)-,mononitrate;Sanorin Spofa;Privine;Privin;Privine (TN);Rhinon;Naftizin;Rinazina;Naphtyzin;Privine nitrate;Prizoliene A;Imidazyl;Septobore;Naphthisen;

 

Naphazoline nitrate Synthetic route

5144-52-5

Naphazoline nitrate

344567-18-6

bis-(2,4-dihydroxythiobenzoyl)sulfinyl

2-(1-naphthylmethyl)-1-(2,4-dihydroxythiobenzoyl)-2-imidazoline

Conditions
ConditionsYield
With pyridine In methanol for 10h; Heating;

Naphazoline nitrate Specification

The IUPAC name of Naphazoline nitrate is 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole; nitric acid. With the CAS registry number 5144-52-5, it is also named as Imidazyl. The classification code is Drug / Therapeutic Agent. It is white solid which is stable under stable temperature and pressure. It is adrenomimetic drug which has pressor function, so it can used in the common cold, rhinitis, nasal congestion, etc. When heated to decomposition it emits toxic fumes of NOx. Additionally, Naphazoline nitrate must be sealed in the container and placed in the cool and dry aera.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.88; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.88; (4)ACD/LogD (pH 7.4): 1.94; (5)ACD/BCF (pH 5.5): 5.25; (6)ACD/BCF (pH 7.4): 5.94; (7)ACD/KOC (pH 5.5): 30.82; (8)ACD/KOC (pH 7.4): 34.89; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Flash Point: 220.2 °C; (13)Enthalpy of Vaporization: 67.07 kJ/mol; (14)Boiling Point: 440.5 °C at 760 mmHg; (15)Vapour Pressure: 1.52E-07 mmHg at 25°C; (16)Rotatable Bond Count: 2; (17)Exact Mass: 273.111341; (18)MonoIsotopic Mass: 273.111341; (19)Topological Polar Surface Area: 90.4; (20)Heavy Atom Count: 20; (21)Complexity: 297.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed, so people should not breathe dust. If you want to contact this product, you must wear suitable protective clothing and gloves. 

People can use the following data to convert to the molecule structure.
1. SMILES:[O-][N+](=O)O.N\1=C(\NCC/1)Cc2cccc3c2cccc3
2. InChI:InChI=1/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4)

The following are the toxicity data which has been tested. 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 66mg/kg (66mg/kg)   Farmaco, Edizione Pratica. Vol. 21, Pg. 204, 1966.
mouse LD50 intravenous 13200ug/kg (13.2mg/kg)   Farmaco, Edizione Pratica. Vol. 21, Pg. 204, 1966.
mouse LD50 oral 265mg/kg (265mg/kg)   Farmaco, Edizione Pratica. Vol. 21, Pg. 204, 1966.
mouse LD50 subcutaneous 170mg/kg (170mg/kg)   Drugs in Japan Vol. 6, Pg. 539, 1982.
rabbit LD50 intravenous 800ug/kg (0.8mg/kg)   Drugs in Japan Vol. 6, Pg. 539, 1982.
rabbit LD50 oral 50mg/kg (50mg/kg)   Drugs in Japan Vol. 6, Pg. 539, 1982.
rabbit LD50 subcutaneous 950ug/kg (0.95mg/kg)   Drugs in Japan Vol. 6, Pg. 539, 1982.
rat LD50 oral 1260mg/kg (1260mg/kg)   Farmaco, Edizione Pratica. Vol. 21, Pg. 204, 1966.
rat LD50 subcutaneous 385mg/kg (385mg/kg)   Drugs in Japan Vol. 6, Pg. 539, 1982.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 5144-52-5