Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Nefopam Hydrochloride

Related Products

Hot Products

Name

Nefopam Hydrochloride

EINECS 245-585-5
CAS No. 23327-57-3 Density 1.064g/cm3
PSA 12.47000 LogP 3.97790
Solubility N/A Melting Point 238-242°
Formula C17H19NO.HCl Boiling Point 369.5 °C at 760 mmHg
Molecular Weight 289.805 Flash Point 109 °C
Transport Information UN 3249 Appearance N/A
Safety 36/37/39-45 Risk Codes 23/24/25
Molecular Structure Molecular Structure of 23327-57-3 (Nefopam hydrochloride) Hazard Symbols T
Synonyms

1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (8CI,9CI);Acupan;Ajan;Fenazoxine hydrochloride;R 738;

Article Data 3

Nefopam Hydrochloride Specification

The Nefopam Hydrochloride is an organic compound with the formula C17H19NO.HCl. The IUPAC name of this chemical is 5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine hydrochloride. With the CAS registry number 23327-57-3, it is also named as Sodium Phenoxyacetate.

Physical properties about Nefopam Hydrochloride are: (1)ACD/LogP: 1.34; (2)ACD/LogD (pH 5.5): -0.98; (3)ACD/LogD (pH 7.4): -2.29; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 46.53 Å2; (12)Flash Point: 115.1 °C; (13)Enthalpy of Vaporization: 55.35 kJ/mol; (14)Boiling Point: 285 °C at 760 mmHg; (15)Vapour Pressure: 0.00135 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].[O-]C(=O)COc1ccccc1
(2)InChI: InChI=1/C8H8O3.Na/c9-8(10)6-11-7-4-2-1-3-5-7;/h1-5H,6H2,(H,9,10);/q;+1/p-1
(3)InChIKey: WPTJBFNYRRZIDZ-REWHXWOFAQ
(4)Std. InChI: InChI=1S/C8H8O3.Na/c9-8(10)6-11-7-4-2-1-3-5-7;/h1-5H,6H2,(H,9,10);/q;+1/p-1
(5)Std. InChIKey: WPTJBFNYRRZIDZ-UHFFFAOYSA-M

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 30mg/kg (30mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
dog LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
dog LD50 oral 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
mouse LD50 intramuscular 53mg/kg (53mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
mouse LD50 intraperitoneal 70mg/kg (70mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
mouse LD50 intravenous 45mg/kg (45mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
mouse LD50 oral 119mg/kg (119mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
rat LD50 intramuscular 57mg/kg (57mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
rat LD50 intravenous 28mg/kg (28mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
rat LD50 oral 80mg/kg (80mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 23327-57-3