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- Neomycin B
- Neomycin B sulphate
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Cas Database |
| Name |
Neomycin B |
EINECS | 204-292-2 |
| CAS No. | 119-04-0 | Density | 1.61 g/cm3 |
| PSA | 353.11000 | LogP | -4.69350 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C23H46 N6 O13 | Boiling Point | 927.1 °C at 760 mmHg |
| Molecular Weight | 614.651 | Flash Point | 514.5 °C |
| Transport Information | N/A | Appearance | Clear Liquid |
| Safety | Poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | 42/43 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
5)]-2-deoxy-;Neomycin B (8CI);Actilin;Actiline;Antibiotic 10676;Antibiotique EF 185;Dekamycin III;Enterfram;Fradiomycin B;Framidal;Framycetin;Framycin;Framygen;Francetin;Fraquinol;Leo Red Dry Cow; |
Article Data | 4 |
Neomycin B Chemical Properties
Chemistry informtion about Neomycin B (CAS NO.119-04-0) is:
IUPAC Name: (2r,3s,4r,5r,6r)-5-Amino-2-(Aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-Diamino-2-[(2s,3r,4s,5r)-4-[(2r,3r,4r,5s,6s)-3-Amino-6-(Aminomethyl)-4,5-Dihydroxyoxan-2-Yl]Oxy-3-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Oxy-3-Hydroxycyclohexyl]Oxyoxane-3,4-Diol
Synonyms: Neomycin Standard ; Neomycin B ; Actilin ; Actiline ; Antibiotique ; Enterfram ; Framycetin ; Framygen
Product Categories: L - ZAlphabetic ; NA - NIMore...Close... ; AminoglycosidesAntibiotics ; Antibacterial ; Antibiotics ; Antibiotics A to ; Antibiotics by Application ; Antibiotics N-SAntibiotics ; Antineoplastic and Immunosuppressive AntibioticsAntibiotics ; Chemical Structure Class ; Genetic Marker SelectionAntibiotics ; Interferes with Protein SynthesisSpectrum of Activity ; Mechanism of Action ; N
MF: C23H46N6O13
MW: 614.64
EINECS: 204-292-2
Density: 1.61 g/cm3
Flash Point: 514.5 °C
Boiling Point: 927.1 °C at 760 mmHg
Enthalpy of Vaporization: 153.02 kJ/mol
Storage temp.: 2-8°C
Merck: 13,6482
Following is the molecular structure of Neomycin B (CAS NO.119-04-0) is:
Neomycin B History
It was discovered in 1949 by the microbiologist Selman Waksman and his student Hubert Lechevalier at Rutgers University. It is produced naturally by the bacterium Streptomyces fradiae.
Neomycin B Uses
Neomycin B (CAS NO.119-04-0) was recommended for use in cell culture applications at 5 ml/L.
Neomycin B Production
Preparation Products is Neomycin Sulfate .
Neomycin B Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 741, 1978. | |
| mouse | LD50 | intravenous | 24mg/kg (24mg/kg) | Journal of Antibiotics. Vol. 27, Pg. 677, 1974. | |
| mouse | LD50 | oral | 1250mg/kg (1250mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 127, 1980. | |
| mouse | LD50 | subcutaneous | 220mg/kg (220mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 2, Pg. 121, 1957. |
Neomycin B Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
Xn
Risk Statements:
R42/43:May cause sensitization by inhalation and skin contact.
R63:Possible risk of harm to the unborn child.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 2
F:
F 8: Photosensitive.
Neomycin B Specification
To protect yourself, you can put on eyeshields, faceshields, full-face respirator (US), gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter.
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