Basic information
- Name:
Nitazoxanide
- CAS No.:
55981-09-4
- Molecular Structure:
- Formula:
- C12H9N3O5S
- Molecular Weight:
- 307.28
- Synonyms:
- Alinia;BRN 1225475;Cryptaz;DRG 0242;N-(5-Nitro-2-thiazolyl)salicylamide acetate(ester);NSC 697855;NTX;Nitacure;Nitacure 500;Nitarid;Nitazox 500;
- EINECS:
- 259-931-8
- Density:
- 1.532 g/cm3
- Melting Point:
- 202 °C
- Appearance:
- Crystalline Solid
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Chemistry
The Molecular Structure of Nitazoxanide (CAS NO.55981-09-4):
Empirical Formula: C12H9N3O5S
Molecular Weight: 307.282
EINECS: 259-931-8
Nominal Mass: 307 Da
Average Mass: 307.282 Da
Monoisotopic Mass: 307.02629 Da
Index of Refraction: 1.673
Molar Refractivity: 75.19 cm3
Molar Volume: 200.4 cm3
Surface Tension: 70.6 dyne/cm
Density: 1.532 g/cm3
Appearance: Crystalline Solid
IUPAC Name: [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
InChI
InChI=1/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
Smiles
c1(c(cccc1)OC(C)=O)C(Nc1sc([N+]([O-])=O)cn1)=O
Synonyms: BRN 1225475 ; PH 5776 ; UNII-SOA12P041N
Nitazoxanide(also known by the brand names Alinia and Annita),it's melting point is about 202°C,it is a light yellow crystalline powder ,poorly soluble in ETHANOL and practically insoluble in water.
Uses
Nitazoxanide (CAS NO.55981-09-4) is a first-line choice for the treatment of illness caused by Cryptosporidium parvum or Giardia lamblia infection in immunocompetent adults and children, and is an option to be considered in the treatment of illness caused by other protozoa and/or helminths. It is used for the treatment of infectious diarrhea caused by Cryptosporidium parvum [7] and Giardia lamblia in patients 1 year of age and older.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD | oral | > 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | JAT, Journal of Applied Toxicology. Vol. 5, Pg. 49, 1985. |
| dog | LD | oral | > 10gm/kg (10000mg/kg) | AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" | JAT, Journal of Applied Toxicology. Vol. 5, Pg. 49, 1985. |
| mouse | LD50 | oral | 1350mg/kg (1350mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS | JAT, Journal of Applied Toxicology. Vol. 5, Pg. 49, 1985. |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS | JAT, Journal of Applied Toxicology. Vol. 5, Pg. 49, 1985. |
Safety Profile
Adverse effects of Nitazoxanide (CAS NO.55981-09-4):
Side effects are mostly gastrointestinal, include abdominal pain, headache, vomiting, nausea and diarrhea.
Specification
Nitazoxanide (CAS NO.55981-09-4) can also be called as Nitazoxanide [USAN:INN] ; (2-((5-Nitro-2-thiazolyl)carbamoyl)phenyl)acetat ; 2-(Acetolyloxy)-N-(5-nitro-2-thiazolyl) benzamide ; Alinia ; Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)- ; N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester) ; N-(5-Nitrothiazol-2-yl)salicylamide acetate ester ; Nitazoxanida ; Nitazoxanida [INN-Spanish] ; Nitazoxanidum ; Nitazoxanidum [INN-Latin] ; Salicylamide, N-(5-nitro-2-thiazolyl)-, acetate (ester) ; o-(N-(5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate .