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| Name |
Nogalamycin |
EINECS | N/A |
| CAS No. | 1404-15-5 | Density | 1.49g/cm3 |
| PSA | 229.44000 | LogP | 1.13800 |
| Solubility | N/A | Melting Point |
195-196° (dec) |
| Formula | C39H49 N O16 | Boiling Point | 899.9°Cat760mmHg |
| Molecular Weight | 773.88 | Flash Point | 498.1°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous and intraperitoneal routes. Human mutation data reported. An antibiotic. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | 45-46-61-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
2,6-Epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylicacid, 11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-a-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-,methyl ester, [2R-(2a,3b,4a,5b,6a,11b,13a,14a)]-; Nogalamycin (7CI,8CI);Antibiotic 205t3; NSC 70845; U 15167 |
Nogalamycin Chemical Properties
Product Name: Nogalamycin
Synonyms of Nogalamycin (CAS NO.1404-15-5) : 2,6-Epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid, 11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R,3S,4R,5R,6R,11S,13S,14R)- ; L-Nogalose ; Methyl ;(1R,10S,12S,13R,21R,22S,23R,24R)-10-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-23-(dimethylamino)-4,8,12,22,24-pentahydroxy-1,12-dimethyl-6,17-dioxo-20,25-dioxahexacyclo[19.3.1.0~2,19~.0~5,18~.0~7,16~.0~9,14~]pentacosa-2,4,7(16),8,14,18-hexaene-13-carboxylate
InChI:InChI=1/C39H49NO16/c1-14-32(49-7)39(4,52-10)33(50-8)36(53-14)54-19-13-37(2,48)24(34(47)51-9)15-11-16-21(27(43)20(15)19)28(44)22-18(41)12-17-30(23(22)26(16)42)55-35-29(45)25(40(5)6)31(46)38(17,3)56-35/h11-12,14,19,24-25,29,31-33,35-36,41,43,45-46,48H,13H2,1-10H3/t14-,19-,24-,25-,29-,31+,32-,33-,35+,36-,37-,38+,39+/m0/s1
Product Categories: Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Inhibits an EnzymeAntibiotics;Interferes with DNA Synthesis;Mechanism of Action
CAS NO:1404-15-5
Molecular Formula:C39H49NO16
Molecular Weight :787.8035
Molecular Structure :.png)
Index of Refraction: 1.648
Surface Tension: 75.9 dyne/cm
Density: 1.49 g/cm3
Flash Point: 498.1 °C
Enthalpy of Vaporization: 137.05 kJ/mol
Boiling Point: 899.9 °C at 760 mmHg
Vapour Pressure: 7.49E-35 mmHg at 25°C
Storage temp: 2-8°C
Nogalamycin Uses
Nogalamycin (CAS NO.1404-15-5) is an anthracycline.
Nogalamycin Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 250ug/kg (0.25mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Progress Report Submitted to the National Cancer Insitute by Piason Research Institute.Vol. -, Pg. 192, 1966. |
| mouse | LD50 | intraperitoneal | 13750ug/kg (13.75mg/kg) | Indian Journal of Experimental Biology. Vol. 17, Pg. 595, 1979. | |
| mouse | LD50 | oral | > 300mg/kg (300mg/kg) | Progress Report Submitted to the National Cancer Insitute by Piason Research Institute.Vol. -, Pg. 192, 1966. | |
| mouse | LDLo | intravenous | 8500ug/kg (8.5mg/kg) | SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER | Progress Report Submitted to the National Cancer Insitute by Piason Research Institute.Vol. -, Pg. 192, 1966. |
| rat | LD50 | intraperitoneal | 500ug/kg (0.5mg/kg) | Advances in Teratology. Vol. 3, Pg. 181, 1968. | |
| rat | LDLo | intravenous | 4600ug/kg (4.6mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES | Progress Report Submitted to the National Cancer Insitute by Piason Research Institute.Vol. -, Pg. 192, 1966. |
Nogalamycin Safety Profile
Poison by intravenous and intraperitoneal routes. Human mutation data reported. An antibiotic. When Nogalamycin (CAS NO.1404-15-5) is heated to decomposition ,it emits toxic fumes of NOx.
Hazard Codes 
T
Risk Statements 45-46-61-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R45:May cause cancer.
R46:May cause heritable genetic damage.
R61:May cause harm to the unborn child.
Safety Statements 53-22-36/37/39-45
WGK Germany 3
RTECS RA4550000
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