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| Name |
Norethynodrel |
EINECS | N/A |
| CAS No. | 68-23-5 | Density | 1.15g/cm3 |
| PSA | 37.30000 | LogP | 3.63660 |
| Solubility | N/A | Melting Point |
169-170° |
| Formula | C20H26 O2 | Boiling Point | 441.6°C at 760 mmHg |
| Molecular Weight | 298.425 | Flash Point | 188.2°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Suspected carcinogen with experimental tumorigenic data. Human and experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. | Risk Codes | R45; R61 |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
19-Nor-17a-pregn-5(10)-en-20-yn-3-one,17-hydroxy- (6CI,8CI); 13-Methyl-17-ethynyl-17-hydroxy-1,2,3,4,6,7,8,9,11,12,13,14,16,17-tetradecahydro-15H-cyclopenta[a]phenanthren-3-one;17-Hydroxy-19-nor-17a-pregn-5(10)-en-20-yn-3-one; 17a-Ethinyl-17b-hydroxy-D5(10)-estren-3-one; 17a-Ethynyl-17-hydroxy-5(10)-estren-3-one; 17a-Ethynyl-17b-hydroxy-5(10)-estrene-3-one; 17a-Ethynyl-17b-hydroxy-D5(10)-estren-3-one; 17a-Ethynylestr-5(10)-ene-17b-ol-3-one; 17a-Ethynylestra-5(10)-ene-17b-ol-3-one; 17b-Hydroxy-19-nor-17a-pregn-5(10)-en-20-yn-3-one;3-Oxo-17b-hydroxy-17a-ethynyl-5(10)-estrene; Enidrel;NSC 15432; Norethinodrel; Norethynodrel; Noretynodrel; SC 4642 |
Norethynodrel Chemical Properties
Chemistry informtion about Norethynodrel(CAS NO.68-23-5) is:
IUPAC Name: (8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
Synonyms: Norethyndrel ; Norethynodrel ; (17-Alpha)-17-Hydroxy-19-Norpregn-5(10)-En-20-Yn-3-One ; (17alpha)-19-Norpregn-5(10)-En-20-Yn-3-On ; 13-Methyl-17-Ethynyl-17-Hydroxy-1,2,3,4,6,7,8,9,11,12,13,14,16,17-Tetradecahyd ; 17-Alpha-Ethinyl-17-Beta-Hydroxy-Delta(Sup5(10))-Estren-3-One ; 17alpha-Ethinyl-17beta-Hydroxy-Delta5(10)-Estren-3-One ; 17-Alpha-Ethinyl-5,10-Estrenolone
MF: C20H26O2
MW: 298.42
EINECS: 200-682-1
Density: 1.15 g/cm3
Flash Point: 188.2 °C
Enthalpy of Vaporization: 80.66 kJ/mol
Boiling Point: 441.6 °C at 760 mmHg
Vapour Pressure: 1.19E-09 mmHg at 25°C
Product Categories: Miscellaneous Biochemicals
Following is the molecular structure of Norethynodrel(CAS NO.68-23-5) is:
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Norethynodrel Uses
Norethynodrel(CAS NO.68-23-5) is a synthetic progestational hormone with actions and uses similar to those of Progesterone. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with Mestranol.
Norethynodrel Toxicity Data With Reference
| 1. | dni-hmn:lyms 50 µmol/L | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 146 (1974),401. | ||
| 2. | dns-rat:lvr 100 µmol/L | CRNGDP Carcinogenesis. 6 (1985),1201. | ||
| 3. | oth-mus-par 16 µg/kg | AJOGAH American Journal of Obstetrics and Gynecology. 120 (1974),390. | ||
| 4. | cyt-mus:oth 10 mg/L | AJOGAH American Journal of Obstetrics and Gynecology. 120 (1974),390. |
Norethynodrel Consensus Reports
IARC Cancer Review: Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 , 1979,p. 461.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 6 , 1974,p. 191.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
Norethynodrel Safety Profile
Suspected carcinogen with experimental tumorigenic data. Human and experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
T
Risk Statements:
R45:May cause cancer.
R61:May cause harm to the unborn child.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: RC8980000
Norethynodrel Specification
Descriptors Computed from Structure about Norethynodrel(CAS NO.68-23-5) is:
Canonical SMILES: CC12CCC3C(C1CCC2(C#C)O)CCC4=C3CCC(=O)C4
Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3CCC(=O)C4
InChI: InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,16-18,22H,4-12H2,2H3/t16-,17-,18+,19+,20+/m1/s1
InChIKey: ICTXHFFSOAJUMG-SLHNCBLASA-N
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