Benzenamine,2-methoxy-

The o-Anisidine with CAS registry number of 90-04-0 is also known as 1-Amino-2-methoxybenzene. The IUPAC name is 2-Methoxyaniline. It belongs to product categories of Intermediates of Dyes and Pigments; Intermediates. Its EINECS registry number is 201-963-1. In addition, the formula is C₇H₉NO and the molecular weight is 123.15. This chemical is a light red or light yellow oily liquid and should be stored in dry, ventilated place without sunlight, moisture and heat.

Physical properties about o-Anisidine are: (1)XLogP3: 1.2; (2)H-Bond Donor: 1; (3)H-Bond Acceptor: 2; (4)Rotatable Bond Count: 1; (5)Exact Mass: 123.068414; (6)MonoIsotopic Mass: 123.068414; (7)Topological Polar Surface Area: 35.2; (8)Heavy Atom Count: 9; (9)Complexity: 85; (10)Covalently-Bonded Unit Count: 1.

Preparation of o-Anisidine: it is prepared by reduction of o-nitrophenyl ether. The o-nitrophenyl ether can be obtained by oxy reaction of o-chlorotoluene. Sodium sulfide or iron can be used as reducing agent. The process is as follows. The first step at 70-78 °C and the second step at 118-120 °C.

(1) C₆H₄NClO₂+CH₃OH+NaOH→C₇H₇NO₃+NaCl+H₂O (2) 4C₇H₇NO₃+6Na₂S+7H₂O→C₇H₆NO+3Na₂S₃O₃+6NaOH

Uses of o-Anisidine: it can be used for making dyes, azoic dyes and naphthol as-ol and other dyes. It also can be used as dyes intermediate. Besides, it is used as reagent for testing codeine and alkaloid. What's more, this chemical is used to prepare pyridine-2-carboxylic acid o-anisidide by reaction with pyridine-2-carbonyl chloride. The reation needs reagent pyridine and the yield is about 40%.

When you are using this chemical, please be cautious about it. As a chemical, it is toxic by inhalation, in contact with skin and if swallowed. It has possible risk of irreversible effects and may cause cancer. During using it, obtain special instructions before use. In case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: COC1=CC=CC=C1N
2. InChI: InChI=1S/C7H9NO/c1-9-7-5-3-2-4-6(7)8/h2-5H,8H2,1H3
3. InChIKey: VMPITZXILSNTON-UHFFFAOYSA-N

The toxicity data is as follows: