Basic information
- Name:
2-Pyrrolidinone,1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-
- CAS No.:
70-22-4
- Molecular Structure:
![Molecular Structure of 70-22-4 (2-Pyrrolidinone,1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-)](http://www.lookchem.com/300w/2010/0711/70-22-4.jpg)
- Formula:
- C12H18 N2 O
- Synonyms:
- 2-Pyrrolidinone,1-[4-(1-pyrrolidinyl)-2-butynyl]- (6CI,8CI,9CI);1-(2-Oxopyrrolidinyl)-4-pyrrolidinyl-2-butyne;1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone;2'-Oxopyrrolidino-1-pyrrolidino-4-butyne; NSC 330497; Oxotremorin;Oxotremorine; Oxytremorine; Tremorine, oxo-
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Chemistry
IUPAC Name: 1-(4-Pyrrolidin-1-ylbut-2-ynyl)pyrrolidin-2-one
Synonyms of Oxotremorine (CAS NO.70-22-4) : 1-(2-Oxo-1-pyrrolidinyl)-4-(1-pyrrolidinyl)-2-butyne ; 1-(4-[1-Pyrrolidinyl]2-butynyl)-2-pyrrolidinone ; 2-Pyrrolidinone, 1-[4- (1-pyrrolidinyl)-2-butynyl]-
InChI: InChI=1/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Alpha sort;H-MAlphabetic;M;MA - MD;Pesticides&Metabolites
CAS NO: 70-22-4
Molecular Formula:C12H18N2O
Molecular Weight :206.28
Molecular Structure :
EINECS: 200-728-0
Index of Refraction: 1.544
Surface Tension: 46.9 dyne/cm
Density: 1.109 g/cm3
Flash Point: 169.1 °C
Enthalpy of Vaporization: 62.12 kJ/mol
Boiling Point: 373.9 °C at 760 mmHg
Vapour Pressure: 8.7E-06 mmHg at 25°C
Storage Temp: 2-8°C
Solubility: H2O: 50 mg/mL
Appearance: Oxotremorine (CAS NO.70-22-4) is clear, light yellow liquid.
Uses
Oxotremorine (CAS NO.70-22-4) is sympathomimetic that acts as a non-selective muscarinic acetylcholine receptor agonist.
Oxotremorine (CAS NO.70-22-4) produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intravenous | 162ug/kg (0.162mg/kg) | LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION | Journal of Pharmaceutical Sciences. Vol. 57, Pg. 1543, 1968. |
| man | TDLo | oral | 7ug/kg (0.007mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | American Journal of Psychiatry. Vol. 144, Pg. 468, 1987. |
| mouse | LD50 | intraperitoneal | 3mg/kg (3mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972. |
| mouse | LD50 | intravenous | 1382ug/kg (1.382mg/kg) | Journal of Medicinal Chemistry. Vol. 28, Pg. 1760, 1985. | |
| mouse | LD50 | oral | 11300ug/kg (11.3mg/kg) | HHS Publication Vol. FDA-80-1076, Pg. 212, 1980. | |
| rat | LD50 | intraperitoneal | 4400ug/kg (4.4mg/kg) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 67, 1969. | |
| rat | LD50 | intravenous | 1220ug/kg (1.22mg/kg) | Fundamental and Applied Toxicology. Vol. 14, Pg. 560, 1990. | |
| women | TDLo | oral | 10ug/kg (0.01mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | American Journal of Psychiatry. Vol. 144, Pg. 468, 1987. |
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes 
T+
C
Risk Statements 28-34
R28:Very toxic if swallowed.
R34:Causes burns.
Safety Statements 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2810 6.1/PG 1
WGK Germany 3
RTECS UY5950100
F 10-23
HazardClass 6.1(a)
PackingGroup I
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