Basic Information | Post buying leads | Suppliers |
Name |
Octamethyl pyrophosphoramide |
EINECS | N/A |
CAS No. | 152-16-9 | Density | 1.171g/cm3 |
PSA | 75.95000 | LogP | 1.46560 |
Solubility | N/A | Melting Point |
17℃ |
Formula | C8H24 N4 O3 P2 | Boiling Point | 319.6°Cat760mmHg |
Molecular Weight | 286.251 | Flash Point | 147.1°C |
Transport Information | N/A | Appearance | N/A |
Safety | Poison by ingestion, inhalation, skin contact, intraperitoneal, intravenous, subcutaneous, and ocular routes. Human systemic effects by ingestion: a cholinesterase inhibitor. Has been found to inhibit peripheral cholinesterase without pronounced effects on the central nervous system. An insecticide. When heated to decomposition it emits toxic fumes of NOx and POx. See also PARATHION and ANHYDRIDES. | Risk Codes | 27/28 |
Molecular Structure | Hazard Symbols | Toxic by ingestion and inhalation, a cholinesterase inhibitor, use may be restricted. | |
Synonyms |
Diphosphoramide,octamethyl- (9CI); Pyrophosphoramide, octamethyl- (8CI);Bis(dimethylamino)phosphonous anhydride; NSC 8929; OMPA; Octamethyl;Octamethylpyrophosphoramide; Octamethylpyrophosphoric acid amide;Octamethylpyrophosphoric acid tetramide; Pestox; Pestox 3; Pestox III;Schradan; Sytam; Tetrakisdimethylaminophosphonous anhydride |
Empirical Formula: C8H24N4O3P2
Molecular Weight: 286.2487 g/mol
EINECS: 205-801-0
Index of Refraction: 1.48
Density: 1.171 g/cm3
Flash Point: 147.1 °C
Enthalpy of Vaporization: 56.12 kJ/mol
Boiling Point: 319.6 °C at 760 mmHg
Vapour Pressure: 0.000335 mmHg at 25 °C
Appearance: Dark brown viscous liquid
Structure of Octamethyl pyrophosphoramide (CAS NO.152-16-9):
IUPAC Name of Octamethyl pyrophosphoramide (CAS NO.152-16-9): N-[Bis(dimethylamino)phosphoryloxy-(dimethylamino)phosphoryl]-N-methylmethanamine
Octamethyl pyrophosphoramide (CAS NO.152-16-9) has been used as an insecticide and as an acaricide, and also has not registered as a pesticide in the U.S.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 11mg/kg (11mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
dog | LD50 | intravenous | 5mg/kg (5mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 376, 1950. |
guinea pig | LD50 | intraperitoneal | 10mg/kg (10mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 376, 1950. | |
man | TDLo | oral | 643ug/kg/30D- (0.643mg/kg) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 603, 1969. | |
mouse | LD50 | intraperitoneal | 10mg/kg (10mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 129, Pg. 699, 1968. | |
mouse | LD50 | intravenous | 9400ug/kg (9.4mg/kg) | Bratislavske Lekarske Listy. Vol. 38, Pg. 151, 1958. | |
mouse | LD50 | oral | 26740ug/kg (26.74mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 181, Pg. 576, 1972. | |
mouse | LD50 | subcutaneous | 10mg/kg (10mg/kg) | Annales Pharmaceutiques Francaises. Vol. 11, Pg. 286, 1953. | |
mouse | LD50 | unreported | 25mg/kg (25mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(5), Pg. 38, 1963. | |
rabbit | LD50 | intravenous | 6mg/kg (6mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 23, Pg. T927, 1964. | |
rabbit | LD50 | oral | 25mg/kg (25mg/kg) | Bulletin of the Entomological Society of America. Vol. 12, Pg. 161, 1966. | |
rabbit | LDLo | ocular | 5mg/kg (5mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 95, 1982. | |
rabbit | LDLo | skin | 20mg/kg (20mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 95, 1982. | |
rat | LCLo | inhalation | 8mg/m3/4H (8mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 95, 1982. | |
rat | LD50 | intraperitoneal | 4900ug/kg (4.9mg/kg) | Japanese Journal of Pharmacology. Vol. 17, Pg. 509, 1967. | |
rat | LD50 | oral | 5mg/kg (5mg/kg) | World Review of Pest Control. Vol. 9, Pg. 119, 1970. | |
rat | LD50 | skin | 15mg/kg (15mg/kg) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969. | |
rat | LD50 | subcutaneous | 9mg/kg (9mg/kg) | Journal of Economic Entomology. Vol. 50, Pg. 356, 1957. | |
rat | LD50 | unreported | 9mg/kg (9mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 379, 1971. |
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
Poison by ingestion, inhalation, skin contact, intraperitoneal, intravenous, subcutaneous, and ocular routes. Human systemic effects by ingestion: a cholinesterase inhibitor. Has been found to inhibit peripheral cholinesterase without pronounced effects on the central nervous system. An insecticide. When heated to decomposition it emits toxic fumes of NOx and POx. See also PARATHION and ANHYDRIDES.
Hazard Codes of Octamethyl pyrophosphoramide (CAS NO.152-16-9): T+
Risk Statements: 27/28
R27:Very toxic in contact with skin.
R28:Very toxic if swallowed.
Safety Statements: 36/37-38-45
S36/37:Wear suitable protective clothing and gloves.
S38:In case of insufficient ventilation, wear suitable respiratory equipment.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Octamethyl pyrophosphoramide ,its cas register number is 152-16-9. It also can be called Schradan ; Diphosphoramide, octamethyl- ;and Bis[bisdimethylaminophosphonous] Anhydride . It is susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides.