Olanzapine (132539-06-1),Olanzapine (132539-06-1) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-
Superlist Name:
Olanzapine
CAS No.:
132539-06-1
Molecular Structure:
Formula:
C₁₇H₂₀N₄S
Molecular Weight:
312.43
Synonyms:
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine;Olansek;10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-;Symbyax;Zyprexa (TN);Olanzapine [USAN:INN];2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine;
Density:
1.32 g/cm³
Melting Point:
195 °C
Boiling Point:
476.035 °C at 760 mmHg
Flash Point:
241.697 °C
Appearance:
yellowish crystalline powder
particular:
particular

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Chemistry

IUPAC Name: 2-Methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
Molecular Formula: C₁₇H₂₀N₄S
Molecular Weight: 312.43 g/mol
SMILES: C=1(c2c(Nc3c(N1)cccc3)sc(c2)C)N1CCN(C)CC1
InChI: InChI=1/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
Classification Code: Antiemetics; Antipsychotic; Antipsychotic agents; Autonomic Agents; Central Nervous System Agents; Central Nervous System Depressants; Gastrointestinal Agents; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Peripheral Nervous System Agents; Psychotropic Drugs; Serotonin Agents; Serotonin Uptake Inhibitors; Tranquilizing Agents
Product Categories: Active Pharmaceutical Ingredients; APIs; Olanzapine; Intermediates & Fine Chemicals; Pharmaceuticals
Solubility: Practically insoluble in water mg/mL (20 °C)
Melting Point: 195 °C
Index of Refraction: 1.709
Molar Refractivity: 92.15 cm³
Molar Volume: 235.9 cm³
Surface Tension: 52 dyne/cm
Density: 1.32 g/cm³
Flash Point: 233.6 °C
Enthalpy of Vaporization: 72.37 kJ/mol
Boiling Point: 462.6 °C at 760 mmHg
Vapour Pressure of Olanzapine (CAS NO.132539-06-1): 9.71E-09 mmHg at 25 °C

Uses

Olanzapine (CAS NO.132539-06-1) is an atypical antipsychotic, approved by the FDA for the treatment of schizophrenia and bipolar disorder.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	16560ug/kg/12 (16.56mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Clinical Psychiatry. Vol. 60, Pg. 767, 1999.
human	TDLo	oral	43mg/kg/30W-I (43mg/kg)		Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 273, 1999.
man	LDLo	oral	7067ug/kg (7.067mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	Journal of Forensic Sciences. Vol. 41, Pg. 1252, 1998.
man	TDLo	oral	2570ug/kg/12D (2.57mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 192, 1999.
women	LDLo	oral	30mg/kg/22W-I (30mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Pharmacotherpy. Vol. 33, Pg. 787, 1999.
women	TDLo	oral	400ug/kg (0.4mg/kg)	BEHAVIORAL: REGIDITY VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	American Journal of Psychiatry. Vol. 156, Pg. 1835, 1999.
women	TDLo	oral	12mg/kg (12mg/kg)	BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Emergency Medicine. Vol. 32, Pg. 275, 1998.
women	TDLo	oral	12mg/kg/60D-I (12mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	Annals of Internal Medicine. Vol. 131, Pg. 72, 1999.

Safety Profile

Human systemic effects. When heated to decomposition it emits toxic vapors of NO_x and SO_x.

Specification

Olanzapine (CAS NO.132539-06-1), its Synonyms are 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine ; Olansek ; Olanzapine Teva ; Olanzapine Mylan ; Olanzapine Neopharma ; Zalasta ; Zypadhera ; Zyprexa ; 10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- . It is yellow crystalline powder.