Omeprazole (73590-58-6) ,Omeprazole (73590-58-6) Manufacturers & Suppliers，MSDS

Basic information

Name:
Omeprazole
CAS No.:
73590-58-6
Molecular Structure:
Formula:
C₁₇H₁₉N₃O₃S
Synonyms:
Pepticus;Zoltum;Lensor;Pepticum;Indurgan;1H-Benzimidazole,5-methoxy-2-[[(4-methoxy- 3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-;Prilosec (TN);Omerprazole;Omisec;Gibancer;Prazidec;Ulzol;Omezolan;Ulsen;Ortanol;Victrix;Omeprazon;Omapren;Zimor;Procelac;Dudencer;5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole;Proclor;Antra;Omesek;Omeprol;Mopral;Gasec;Peptilcer;Nopramin;Tedec Ulceral;Omid;Zegerid;Result;Ulcesep;Gastroloc;Losec;Ompanyt;2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole;Omed;Prilosec OTC;Antra MUPS;Omeprazolum [INN-Latin];Omebeta 20;Omizac;Zepral;Demeprazol;Ozoken;Omegast;Zefxon;Omeprazol [INN-Spanish];Danlox;Ceprandal;Olexin;Belmazol;Ulcometion;Erbolin;Miracid;Osiren;Prazolit;Ulcozol;Inhipump;Nilsec;Exter;Regulacid;

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Chemistry

IUPAC Name: 6-Methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Molecular Formula: C₁₇H₁₉N₃O₃S
Molecular Weight: 345.42 g/mol
SMILES: c12c([nH]c(n1)[S@@](Cc1c(c(c(C)cn1)OC)C)=O)ccc(c2)OC
InChI: InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
Classification Code: Anti-ulcer agents; Depressant [gastric acid secretory]; Drug / Therapeutic Agent; Enzyme inhibitors; Gastrointestinal Agents; Human Data; Mutation data; Reproductive Effect
Product Categories: Drug bulk; Active Pharmaceutical Ingredients; Omeprazole; Intermediates & Fine Chemicals; Pharmaceuticals; API's; ATPase
Stability: Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.
Melting Point: 156 °C
storage temperature: 2-8 °C
solubility: H₂O: 0.5 mg/mL
Index of Refraction: 1.669
Molar Refractivity: 94.02 cm³
Molar Volume: 251.8 cm³
Polarizability: 37.27×10^-24 cm³
Surface Tension: 75.1 dyne/cm
Density: 1.37 g/cm³
Flash Point: 316.7 °C
Enthalpy of Vaporization: 89.31 kJ/mol
Boiling Point: 600 °C at 760 mmHg
Vapour Pressure of Omeprazole (CAS NO.73590-58-6): 2.35E-14 mmHg at 25 °C

Uses

Omeprazole (CAS NO.73590-58-6) is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger-Ellison syndrome. Omeprazole is combined with the antibiotics clarithromycin and amoxicillin in the 7-14 day eradication triple therapy for Helicobacter pylori.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	unreported	> 600mg/kg (600mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 33, Pg. 782, 1991.
man	TDLo	oral	4mg/kg/2W-I (4mg/kg)	MUSCULOSKELETAL: JOINTS	Lancet. Vol. 345, Pg. 461, 1995.
mouse	LD50	intraperitoneal	> 100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988.
mouse	LD50	intravenous	82800ug/kg (82.8mg/kg)		Scandinavian Journal of Gastroenterology, Supplement. Vol. 108, Pg. 53, 1985.
mouse	LD50	oral	> 4gm/kg (4000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988.
mouse	LD50	subcutaneous	> 100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988.
rat	LD50	intraperitoneal	> 100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988.
rat	LD50	intravenous	> 50mg/kg (50mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988.
rat	LD50	oral	2210mg/kg (2210mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988.
rat	LD50	subcutaneous	> 100mg/kg (100mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988.
women	TDLo	oral	800ug/kg/2D-I (0.8mg/kg)	LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION LUNGS, THORAX, OR RESPIRATION: COUGH	Pharmacotherapy Vol. 14, Pg. 119, 1993.
women	TDLo	oral	4400ug/kg/11D (4.4mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	American Journal of Gastroenterology. Vol. 94, Pg. 1119, 1999.
women	TDLo	oral	24mg/kg/60D-I (24mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: NORMOCYTIC ANEMIA	Postgraduate Medical Journal. Vol. 74, Pg. 416, 1998.
women	TDLo	oral	30mg/kg/10W-I (30mg/kg)	BLOOD: EOSINOPHILIA KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	American Journal of Medicine. Vol. 95, Pg. 248, 1993.
women	TDLo	oral	36400ug/kg/13 (36.4mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Journal of Clinical Gastroenterology. Vol. 25, Pg. 718, 1997.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS of Omeprazole (CAS NO.73590-58-6): DD9087000

Specification

Omeprazole (CAS NO.73590-58-6), its Synonyms are ( -)-Omeprazole ; 1H-Benzimidazole, 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)- ; 2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole ; 5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole ; Antra MUPS ; Audazol . It is white crystalline solid.

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Basic information

Omeprazole

73590-58-6

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