Basic information
- Name:
Oxcarbazepine
- CAS No.:
28721-07-5
- Molecular Structure:
- Formula:
- C15H12N2O2
- Molecular Weight:
- 252.27 .
- Synonyms:
- Trileptal;GP 47680;5H-Dibenz(b,f)azepine-5-carboxamide, 10,11-dihydro-10-oxo-;Oxcarbazepine (USAN);Trileptal (TN);Oxcarbazepine [INN];Oxcarbazepina [INN-Spanish];10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide;Oxcarbazepinum [INN-Latin];
- EINECS:
- 249-188-8
- Density:
- 1.329 g/cm3
- Melting Point:
- 215-216 °C
- Boiling Point:
- 457.2 °C at 760 mmHg
- Flash Point:
- 230.3 °C
- Solubility:
- DMSO: ~9 mg/mL
- Appearance:
- Pale yellow powder
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
History
In 1966,Oxcarbazepine(28721-07-5): was first synthesized, and it wasapproved for use as an anticonvulsant in Denmark in 1990. It was approved in Spain in 1993, in Portugal in 1997, and eventually for all other EU countries in 1999. It was approved in the US in 2000.
Specification
The Oxcarbazepine is an organic compound with the formula C15H12N2O2. The IUPAC name of this chemical is 5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide. With the CAS registry number 28721-07-5, it is also named as 10-Oxo-10,11-dihydro-5H-dibenzo[b,f]azepin-5-carboxamid. The product's categories are Heterocyclic Compounds; APIs; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it is a pale yellow powder, which is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder, and also used to treat anxiety disorders.
Physical properties about Oxcarbazepine are: (1)ACD/LogP: 1.44; (2)ACD/LogD (pH 5.5): 1.44; (3)ACD/LogD (pH 7.4): 1.44; (4)ACD/BCF (pH 5.5): 7.27; (5)ACD/BCF (pH 7.4): 7.27; (6)ACD/KOC (pH 5.5): 143.92; (7)ACD/KOC (pH 7.4): 143.92; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)Polar Surface Area: 40.62 Å2; (11)Index of Refraction: 1.661; (12)Molar Refractivity: 70.21 cm3; (13)Molar Volume: 189.7 cm3; (14)Polarizability: 27.83×10-24cm3; (15)Surface Tension: 61.2 dyne/cm; (16)Density: 1.329 g/cm3; (17)Flash Point: 230.3 °C; (18)Enthalpy of Vaporization: 71.73 kJ/mol; (19)Boiling Point: 457.2 °C at 760 mmHg; (20)Vapour Pressure: 1.52E-08 mmHg at 25°C.
Preparation: this chemical can be prepared by 10 - methoxy-5H-dibenzo [b, f] aza and phosgene in toluene environment. Reaction is as follows:
.PNG)
You can still convert the following datas into molecular structure:
(1)SMILES: O=C3c1c(cccc1)N(c2ccccc2C3)C(=O)N
(2)InChI: InChI=1/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
(3)InChIKey: CTRLABGOLIVAIY-UHFFFAOYAH
(4)Std. InChI: InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
(5)Std. InChIKey: CTRLABGOLIVAIY-UHFFFAOYSA-N