Basic Information | Post buying leads | Suppliers |
Name |
Oxethazaine |
EINECS | 204-780-5 |
CAS No. | 126-27-2 | Density | 1.094 g/cm3 |
PSA | 64.09000 | LogP | 3.24010 |
Solubility | <0.1 g/100 mL at 23 °C in water | Melting Point |
104-105°C |
Formula | C28H41N3O3 | Boiling Point | 630.412 °C at 760 mmHg |
Molecular Weight | 467.652 | Flash Point | 335.062 °C |
Transport Information | N/A | Appearance | White powder |
Safety | 36 | Risk Codes | 22 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
Acetamide,2,2'-[(2-hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methyl-(6CI,7CI,8CI);2,2'-[(2-Hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methylacetamide];2-Di(N-methyl-N-phenyl-tert-butyl-carbamoylmethyl)aminoethanol;Betalgil;FH099;Mucoxin;Oxaine;Oxetacaine;Storocain;Storocaine;Topicain; |
Conditions | Yield |
---|---|
With potassium carbonate; butan-1-ol |
chloro-acetic acid-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]
ethanolamine
oxethazaine
Conditions | Yield |
---|---|
With potassium carbonate In butan-1-ol |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene 2: K2CO3 / butan-1-ol View Scheme |
oxethazaine
acetic anhydride
(2-acetoxy-ethylimino)-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]
Conditions | Yield |
---|---|
In benzene Heating; | |
With potassium carbonate; toluene |
p-nitrobenzoic anhydride
oxethazaine
[2-(4-nitro-benzoyloxy)-ethylimino]-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]
Conditions | Yield |
---|---|
In benzene Heating; |
Conditions | Yield |
---|---|
In benzene Heating; |
p-methylbenzoic anhydride
oxethazaine
Conditions | Yield |
---|---|
In benzene Heating; |
oxethazaine
Conditions | Yield |
---|---|
In benzene Heating; |
oxethazaine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether |
oxethazaine
(2-chloro-ethylimino)-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]
Conditions | Yield |
---|---|
With thionyl chloride In chloroform |
IUPAC Name: Oxethazaine
The MF of Oxethazaine (126-27-2) is C28H41N3O3.
The MW of Oxethazaine (126-27-2) is 467.64.
Synonyms of Oxethazaine (126-27-2): 2,2'-[(2-Hydroxyethyl)imino]bis[N(1,1-dimethyl-2-phenylethyl)-N-methylacetamide] ; 2,2'-[(2-Hydroxyethyl)imino]bis[N-methyl-N-(2-methyl-1-phenyl-2-propanyl)acetamide] ; Acetamide, 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methyl- ; N,N-Bis[N-methyl-N-phenyl-tert-butylacetamido]-b-hydroxyethylamine ; Oxaine M ; Oxethazine
Water Solubility: <0.1 g/100 mL at 23 ºC
Index of Refraction: 1.557
Form: White powder
EINECS: 204-780-5
Density: 1.093 g/ml
Flash Point: 335.1 °C
Boiling Point: 630.4 °C
Melting Point: 104-105 °C
1. | sln-asn 1 mg/L | MUREAV Mutation Research. 26 (1974),159. | ||
2. | ipr-rat LD50:30 mg/kg | GMITAB Gazzetta Medica Italiana. 134 (1975),642. | ||
3. | ipr-mus LD50:27 mg/kg | GMITAB Gazzetta Medica Italiana. 134 (1975),642. | ||
4. | scu-mus LD50:58 mg/kg | GMITAB Gazzetta Medica Italiana. 134 (1975),642. |
Poison by intraperitoneal and subcutaneous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Safety information of Oxethazaine (126-27-2):
Hazard Codes Xn
Risk Statements
22 Harmful if swallowed
Safety Statements
36 Wear suitable protective clothing
WGK Germany 3
RTECS AC3325000
A hydroxylated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).