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Oxethazaine

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Name

Oxethazaine

EINECS 204-780-5
CAS No. 126-27-2 Density 1.094 g/cm3
PSA 64.09000 LogP 3.24010
Solubility <0.1 g/100 mL at 23 °C in water Melting Point 104-105°C
Formula C28H41N3O3 Boiling Point 630.412 °C at 760 mmHg
Molecular Weight 467.652 Flash Point 335.062 °C
Transport Information N/A Appearance White powder
Safety 36 Risk Codes 22
Molecular Structure Molecular Structure of 126-27-2 (Oxethazaine) Hazard Symbols HarmfulXn
Synonyms

Acetamide,2,2'-[(2-hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methyl-(6CI,7CI,8CI);2,2'-[(2-Hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methylacetamide];2-Di(N-methyl-N-phenyl-tert-butyl-carbamoylmethyl)aminoethanol;Betalgil;FH099;Mucoxin;Oxaine;Oxetacaine;Storocain;Storocaine;Topicain;

 

Oxethazaine Synthetic route

26187-18-8

2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide

141-43-5

ethanolamine

126-27-2

oxethazaine

Conditions
ConditionsYield
With potassium carbonate; butan-1-ol
2293-55-2

chloro-acetic acid-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

141-43-5

ethanolamine

126-27-2

oxethazaine

Conditions
ConditionsYield
With potassium carbonate In butan-1-ol
100-92-5

mephentermine

126-27-2

oxethazaine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene
2: K2CO3 / butan-1-ol
View Scheme
126-27-2

oxethazaine

108-24-7

acetic anhydride

103170-15-6

(2-acetoxy-ethylimino)-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

Conditions
ConditionsYield
In benzene Heating;
With potassium carbonate; toluene
902-47-6

p-nitrobenzoic anhydride

126-27-2

oxethazaine

97615-58-2

[2-(4-nitro-benzoyloxy)-ethylimino]-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

Conditions
ConditionsYield
In benzene Heating;
645-66-9

lauric anhydride

126-27-2

oxethazaine

Ester aus Dodecansaeure u. 2-Hydroxy-aethylimino-bis-

Conditions
ConditionsYield
In benzene Heating;
13222-85-0

p-methylbenzoic anhydride

126-27-2

oxethazaine

Ester aus 4-Methyl-benzoesaeure u. 2-Hydroxy-aethylimino-bis-

Conditions
ConditionsYield
In benzene Heating;
126-27-2

oxethazaine

4-aminobenzoic anhydride

4-Amino-benzoic acid 2-(bis-{[(1,1-dimethyl-2-phenyl-ethyl)-methyl-carbamoyl]-methyl}-amino)-ethyl ester

Conditions
ConditionsYield
In benzene Heating;
126-27-2

oxethazaine

N.N-Bis-

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether
126-27-2

oxethazaine

115916-47-7

(2-chloro-ethylimino)-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

Conditions
ConditionsYield
With thionyl chloride In chloroform

Oxethazaine Chemical Properties

IUPAC Name: Oxethazaine
The MF of Oxethazaine (126-27-2) is C28H41N3O3.

               
The MW of Oxethazaine (126-27-2) is 467.64.
Synonyms of Oxethazaine (126-27-2): 2,2'-[(2-Hydroxyethyl)imino]bis[N(1,1-dimethyl-2-phenylethyl)-N-methylacetamide] ; 2,2'-[(2-Hydroxyethyl)imino]bis[N-methyl-N-(2-methyl-1-phenyl-2-propanyl)acetamide] ; Acetamide, 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methyl- ; N,N-Bis[N-methyl-N-phenyl-tert-butylacetamido]-b-hydroxyethylamine ; Oxaine M ; Oxethazine
Water Solubility: <0.1 g/100 mL at 23 ºC
Index of Refraction: 1.557  
Form: White powder
EINECS: 204-780-5
Density: 1.093 g/ml 
Flash Point: 335.1 °C 
Boiling Point: 630.4 °C
Melting Point: 104-105 °C

Oxethazaine Toxicity Data With Reference

1.    

sln-asn 1 mg/L

    MUREAV    Mutation Research. 26 (1974),159.
2.    

ipr-rat LD50:30 mg/kg

    GMITAB    Gazzetta Medica Italiana. 134 (1975),642.
3.    

ipr-mus LD50:27 mg/kg

    GMITAB    Gazzetta Medica Italiana. 134 (1975),642.
4.    

scu-mus LD50:58 mg/kg

    GMITAB    Gazzetta Medica Italiana. 134 (1975),642.

Oxethazaine Safety Profile

Poison by intraperitoneal and subcutaneous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Safety information of Oxethazaine (126-27-2):
Hazard Codes  Xn
Risk Statements 
22  Harmful if swallowed
Safety Statements 
36  Wear suitable protective clothing
WGK Germany  3
RTECS  AC3325000

Oxethazaine Specification

A hydroxylated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

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