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Name	PICROTOXIN	EINECS	N/A
CAS No.	124-87-8	Density	g/cm³
PSA	190.95000	LogP	-0.92920
Solubility	4.083g/L(room temperature)	Melting Point	203 °C(lit.)
Formula	C₁₅H₁₈O₇•C₁₅H₁₆O₆	Boiling Point	595.8°Cat760mmHg
Molecular Weight	602.592	Flash Point	228.9°C
Transport Information	N/A	Appearance	N/A
Safety	A human poison by ingestion. Poison experimentally by most routes. Human systemic effects by ingestion: somnolence, gastrointestinal effects. An alkaloid convulsant poison. When heated to decomposition it emits acrid smoke and irritating fumes.	Risk Codes	28-52/53
Molecular Structure		Hazard Symbols	Toxic in overdose.
Synonyms	)-3,6-methano-8h-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3h)-dione(;1:1)[qr];3,6-methano-8h-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3h)-dione,hex;3beta,6beta,6abeta,8as,8bbeta,9s))-,compdwith(1ar-(1aalpha,2abeta,3beta,6b;ahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-,(1ar-(1aalpha,2abeta,;ai3-17689[qr];caswellno663a[qr];cocculin[qr]

PICROTOXIN Chemical Properties

Product Name: Picrotoxin
Synonyms: 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione(1:1)[qr] ; 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione,hex ; Ahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-(1ar-(1aalpha,2abeta),ai3)-17689[qr] ; Caswellno663a[qr] ; Cocculin[qr]
Product Categories: GABA/Glycine receptor
CAS NO: 124-87-8
Melting point: C₃₀H₃₄O₁₃
Molecular Weight: 602.58
Molecular Structure:
EINECS: 204-716-6
Merck : 7415
Mol File: 124-87-8.mol
Flash Point: 228.9 °C
Enthalpy of Vaporization: 101.87 kJ/mol
Boiling Point: 595.8 °C at 760 mmHg
Vapour Pressure: 1.12E-16 mmHg at 25°C
Melting point: 203 °C(lit.)
Density 1,28 g/cm³
Solubility ethanol: 50 mg/mL, clear to slightly hazy
Appearance: Picrotoxin (CAS NO.124-87-8) is white to off-white powder or crystals.

PICROTOXIN Toxicity Data With Reference

1.	orl-hmn LDLo:357 µg/kg:CNS,GIT	34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,476.
2.	ipr-rat LD50:1990 µg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),996.
3.	scu-rat LD50:2880 µg/kg	JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 38 (1949),604.
4.	ivn-rat LD50:1600 µg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),996.
5.	orl-mus LD50:15 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 128 (1960),176.
6.	ipr-mus LD50:11 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 13 (1968),307.
7.	scu-mus LD50:4100 µg/kg	RPOBAR Research Progress in Organic Biological and Medicinal Chemistry. 1 (1964),423.
8.	ivn-mus LD50:2440 µg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 135 (1962),9.
9.	scu-dog LDLo:1500 µg/kg	HBAMAK “Abdernalden’s Handbuch der Biologischen Arbeitsmethoden.“ 4 (1935),1385.
10.	ims-dog LD

PICROTOXIN Consensus Reports

EPA Extremely Hazardous Substances List.

PICROTOXIN Safety Profile

A human poison by ingestion. Poison experimentally by most routes. Human systemic effects by ingestion: somnolence, gastrointestinal effects. An alkaloid convulsant poison. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes Very T+T, Dangerous N
Risk Statements 28-52/53
R28:Very toxic if swallowed.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements 28-36/37/39-45-61
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS TJ9100000
F 8-10
Hazard Note Very Toxic
HazardClass 6.1(a)
PackingGroup I

PICROTOXIN Standards and Recommendations

DOT Classification: 6.1; Label: Poison

PICROTOXIN Specification

1.General Description: A poisonous berry, the dried fruit of Anamirta Picrotoxinl. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent.
2.Reactivity Profile: Picrotoxin (CAS NO.124-87-8) contains picrotoxin, a molecular compound of picrotoxinin and picrotin. May react with strong oxidizing agents and with strong reducing agents.
3.Health Hazard : Picrotoxin (CAS NO.124-87-8) is highly toxic and a dose of 20 mg may produce symptoms of severe poisoning. A human lethal dose of 1.5 mg/kg has been reported. It is an alkaloid convulsant poison.
4.Fire Hazard: When heated to decomposition Picrotoxin emits acrid smoke and fumes. Avoid decomposing heat.

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