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POTASSIUM CANRENOATE

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POTASSIUM CANRENOATE

EINECS 218-554-9
CAS No. 2181-04-6 Density g/cm3
PSA 77.43000 LogP 2.55550
Solubility Very soluble in water; soluble in alcohol; insoluble in coloroform and Melting Point N/A
Formula C22H30 O4 . K Boiling Point °Cat760mmHg
Molecular Weight 396.568 Flash Point °C
Transport Information N/A Appearance Light yellow to tan powder
Safety Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. A steroid. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes of K2O. Risk Codes R22   
Molecular Structure Molecular Structure of 2181-04-6 (Potassium canrenoate) Hazard Symbols
Synonyms

17a-Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, monopotassium salt (8CI); 17a-Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, potassium salt (7CI); Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, monopotassium salt, (17a)- (9CI); 17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylicacid potassium salt; Aldadiene Kalium; Aldadiene potassium; Aldadiene potassiumsalt; CB 8109; Canrenoate potassium; Kanrenol; MF 465 a; Potassium17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylate; Potassium 3-(17b-hydroxy-3-oxoandrosta-4,6-dien-17-yl)propionate;Potassium 3-(3-oxo-17b-hydroxy-4,6-androstadien-17a-yl)propionate; Potassium aldadiene; Potassium canrenoate; Potassium b-(3-oxo-17b-hydroxyandrosta-4,6-dien-17a-yl)propionate; SC 14266; SC14266/371; Soldactona; Soldactone; Soludactone; Venactone

 

POTASSIUM CANRENOATE Chemical Properties

Product Name: Potassium 3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate
Synonyms: Aldadiene-potassium ; Canrenoate Potassium ;Canrenone free acid potassium salt ; Potassium 17-hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylate ; Potassium 17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylate ; Potassium 3-(17-beta-hydroxy-3-oxoandrosta-4,6-dien-17-yl)propionate ; Potassium 3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate (non-preferred name)
Molecular Structure :
Molecular Formula : C22H29KO4
Molecular Weight : 396.56
CAS NO: 2181-04-6
EINECS: 218-554-9
Appearance: Potassium canrenoate (CAS NO.2181-04-6) is color light yellow to tan powder.

POTASSIUM CANRENOATE Uses

 Potassium canrenoate (CAS NO.2181-04-6) is for the metabolites of spironolactone Canrenoate acid potassium salt, role similar to spironolactone, but a lesser role in the feminization of male breast, it can be used as alternative medicine, mainly for heart failure, edema, and cirrhosis with ascites.
 

POTASSIUM CANRENOATE Toxicity Data With Reference

1.    

mic-mus:lym 150 mg/L

    ARTODN    Archives of Toxicology. 61 (1988),201.
2.    

orl-rat LD50:650 mg/kg

    NICHAS    Nichidai Igaku Zasshi. 36 (1977),7.
3.    

ipr-rat LD50:183 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
4.    

scu-rat LD50:160 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
5.    

ivn-rat LD50:112 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
6.    

orl-mus LD50:740 mg/kg

    NICHAS    Nichidai Igaku Zasshi. 36 (1977),7.
7.    

ipr-mus LD50:140 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 149 (1964),8.
8.    

scu-mus LD50:165 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
9.    

ivn-mus LD50:125 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.

POTASSIUM CANRENOATE Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. A steroid. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes of K2O.
Hazard Codes HarmfulXn
Risk Statements 22
R22: Potassium canrenoate (CAS NO.2181-04-6) is harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
WGK Germany 3
RTECS TU3500000

 

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