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Potassium clavulanate

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Name

Potassium clavulanate

EINECS 262-640-9
CAS No. 61177-45-5 Density
Solubility Melting Point >160 °C
Formula C8H8KNO5 Boiling Point 545.8 °C at 760 mmHg
Molecular Weight 237.25 Flash Point 283.9 °C
Transport Information Appearance Pale yellowish solid
Safety Risk Codes
Molecular Structure Molecular Structure of 61177-45-5 (Potassium clavulanate) Hazard Symbols
Synonyms

4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)- (9CI);4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, [2R-(2a,3Z,5a)]-;Clavitesse;Clavulanate potassium;Clavulanic acid potassium salt;4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3-(2-hydroxyethylidene)-7-oxo-, potassium salt (1:1), (2R,3Z,5R)-;

 

Chemistry


IUPAC Name: Potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
Molecular Formula: C8H8KNO5
Molecular Weight: 237.25 g/mol
SMILES: N12[C@H](\C(=C\CO)O[C@@H]1CC2=O)C(=O)[O-].[K+]
InChI: InChI=1/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
EINECS: 262-640-9
Classification Code: Antibacterial; Inhibitor [beta-lactamase]; Reproductive Effect
Flash Point: 283.9 °C 
Enthalpy of Vaporization: 94.82 kJ/mol 
Boiling Point: 545.8 °C at 760 mmHg 
Melting Point: >160 °C  (dec)
storage temperature: 2-8 °C
Vapour Pressure of Potassium clavulanate (CAS NO.61177-45-5): 3.45E-14 mmHg at 25 °C

Uses

  Potassium clavulanate (CAS NO.61177-45-5) used as a -Lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Chemotherapy Vol. 34(Suppl,
mouse LD50 intraperitoneal 1531mg/kg (1531mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
mouse LD50 intravenous 348mg/kg (348mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 34(Suppl,
mouse LD50 oral 4526mg/kg (4526mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
mouse LD50 subcutaneous 2185mg/kg (2185mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rat LD50 intramuscular 1680mg/kg (1680mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Chemotherapy Vol. 34(Suppl,
rat LD50 intraperitoneal 1399mg/kg (1399mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rat LD50 intravenous 326mg/kg (326mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 34(Suppl,
rat LD50 oral 7936mg/kg (7936mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,
rat LD50 subcutaneous 1398mg/kg (1398mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 31(Suppl,

Safety Profile

Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Na2O and K2O.

Specification

  Potassium clavulanate (CAS NO.61177-45-5), its Synonyms are 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R-(2alpha,3Z,5alpha))- ; Amonate ; Clavulansaeure kaliumsalz ; Clavulanate potassium . It is pale yellowish solid.

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