Basic information
- Name:
Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,hydrochloride (1:2)
- Superlist Name:
- Puromycin dihydrochloride
- CAS No.:
58-58-2
- Molecular Structure:
![Molecular Structure of 58-58-2 (Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,hydrochloride (1:2))](http://www.lookchem.com/300w/2010/0622/58-58-2.jpg)
- Formula:
- C22H29 N7 O5 . 2 Cl H
- Molecular Weight:
- 544.50
- Synonyms:
- Adenosine,3'-(a-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-,dihydrochloride, L- (8CI); Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,dihydrochloride (9CI); Adenosine,3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-,dihydrochloride, (S)-; 3'-(L-a-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosinedihydrochloride; CL 13900 dihydrochloride; CL 16,536; CL 16536; NSC 3055; P 638dihydrochloride; PDH; Puromycin dihydrochloride; Puromycin hydrochloride;Stylomycin dihydrochloride
- EINECS:
- 200-387-8
- Density:
- g/cm3
- Boiling Point:
- °Cat760mmHg
- Flash Point:
- °C
- Solubility:
- Stability Stable. Heat sensitive. Incompatible with strong oxidizing agents. Toxicology Harmful if swallowed. Toxicity data (The meaning of any toxicological abb
- Appearance:
- white powder
- Hazard Symbols:
Xn- Risk Codes:
- 22
- Safety Description:
- Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl. Details
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Chemistry
IUPAC Name: 2-Amino-N-[(2S,3R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
The molecular formula of Puromycin dihydrochloride (CAS NO.58-58-2) is C22H31Cl2N7O5.
The molecular weight of Puromycin dihydrochloride (CAS NO.58-58-2) is 544.43.
Synonyms of Puromycin dihydrochloride (CAS NO.58-58-2): L-3'-(A-Amino-P-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine dihydrochloride ; Stylomycin dihydrochloride
Stability: Stable. Heat sensitive. Incompatible with strong oxidizing agents
Product Categories: Antibiotics
Appearance: white powder
Storage temp: -20 °C
Flash Point: 460.6 °C
Boiling Point: 838 °C
EINECS: 200-387-8
Uses
Puromycin dihydrochloride (CAS NO.58-58-2) is used as chemical reagent, organic intermediates, fine chemicals, pharmaceutical research and development.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intramuscular | 202mg/kg (202mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| guinea pig | LD50 | intramuscular | 202mg/kg (202mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| guinea pig | LD50 | intraperitoneal | 287mg/kg (287mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| guinea pig | LD50 | intraperitoneal | 287mg/kg (287mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| guinea pig | LD50 | oral | 600mg/kg (600mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| guinea pig | LD50 | oral | 600mg/kg (600mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| mouse | LD50 | intraperitoneal | 580mg/kg (580mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| mouse | LD50 | intraperitoneal | 580mg/kg (580mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| mouse | LD50 | intravenous | 335mg/kg (335mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| mouse | LD50 | intravenous | 335mg/kg (335mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
| mouse | LD50 | oral | 720mg/kg (720mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
| mouse | LD50 | oral | 720mg/kg (720mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
Safety Profile
Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl.Safety information of Puromycin dihydrochloride (CAS NO.58-58-2):
Hazard Codes 
Xn
Risk Statements
22 Harmful if swallowed
40 Limited evidence of a carcinogenic effect
RIDADR 3249
WGK Germany 3
RTECS AU7355000
F 3-8-10
HazardClass 6.1(b)
PackingGroup III