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Pancreatin

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Name

Pancreatin

EINECS 232-468-9
CAS No. 8049-47-6 Density
Solubility Melting Point
Formula Boiling Point
Molecular Weight Flash Point
Transport Information Appearance cream powder
Safety 22-24-26-36-37/39 Risk Codes 36/37/38-42-42/43
Molecular Structure Molecular Structure of 8049-47-6 (Pancreatin) Hazard Symbols HarmfulXn
Synonyms

Beef viokase;Diastase vera;HSDB 1976;llozyme;Intrazyme;Norzyme;Pancreatic enzymes;Pancreatic extract;Pancrelipase;Pancrex-V;Pankreon;Pankrotanon;Panteric;UNII-FQ3DRG0N5K;Viobin;Viokase;Zypanar;

 

Chemistry

Product Name: Pancreatin
Synonyms of Pancreatin (CAS NO.8049-47-6): Beef viokase ; Diastase vera ; EINECS 232-468-9 ; HSDB 1976 ; Ilozyme ; Intrazyme ; Norzyme ; Pancreatic enzymes ; Pancreatic extract ; Pancrelipase ; Pancrex-V ; Pankreon ; Pankrotanon ; Panteric ; UNII-FQ3DRG0N5K ; Viobin ; Viokase ; Zypanar
CAS NO: 8049-47-6
Classification Code: Drug / Therapeutic Agent ; Enzyme [digestant adjunct] ; Gastrointestinal agents ; TSCA Flag XU [Exempt from reporting under the Inventory Update Rule]
Storage temp.: −20°C
Form: powder
Merck: 13,7075
Stability: Stable. Incompatible with alcohols, strong acids.

Uses

 Pancreatin (CAS NO.8049-47-6) can be used for the goods donated for the lack of pancreatic indigestion. Also for the leather and textile industries, mainly for hair removal method.

Production

 Pancreatin (CAS NO.8049-47-6) is produced by activation, extraction, precipitation, degreasing, drying, crushing of milled pig pancreas.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2100mg/kg (2100mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
mouse LD50 subcutaneous 3870mg/kg (3870mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
rat LD50 intraperitoneal 2550mg/kg (2550mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
rat LD50 oral > 10gm/kg (10000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 36/37/38-42/43 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-24-26-36-37/39 
S22: Do not breathe dust. 
S24: Avoid contact with skin. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing. 
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 1
RTECS: RT9033000
F: 3-10
HS Code: 35079090 
Moderately toxic by subcutaneous and intraperitoneal routes.

Specification

Precautions of Pancreatin (CAS NO.8049-47-6): Do not ingest. Do not breathe dust. Keep away from heat. Keep away from sources of ignition. If ingested, seek medical advice immediately and show the container or the label. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. 

Storage of Pancreatin (CAS NO.8049-47-6): Keep container tightly closed. Keep in a cool, well-ventilated place. Keep in a cool place. Keep container dry. Ground all equipment containing material. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents.

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