Pentamidine isethionate (140-64-7),Pentamidine isethionate (140-64-7) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Pentamidine isethionate
CAS No.:
140-64-7
Molecular Structure:
Formula:
C₁₉H₂₄N₄O₂^.2(C₂H₆O₄S)
Molecular Weight:
592.69
Synonyms:
Pentamidine diisethionate;Prestwick_857;4,4-Diamidino-alpha,omega-diphenoxypentane isethionate;Pentam 300 (TN);p,p-(Pentamethylenedioxy)dibenzamidine bis(beta-hydroxyethanesulfonate);4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide; 2-hydroxyethanesulfonic acid;Pentacarinat;Lomidine;Pneumopent;RP 2512;4,4-Diamidinodiphenoxypentane di(beta-hydroxyethanesulfonate);WR 4931;USAF XR-10;Pentam 300;Nebupent;Lomidin;Benzamidine, 4,4-(pentamethylenedioxy)di-, bis(beta-hydroxyethanesulfonate);Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4-(1,5-pentanediylbis(oxy))bis(benzenecarboximidamide) (2:1);R.P. 2512;Pentamidine isetionate;Lomidine isoethionate;
EINECS:
205-424-1
Melting Point:
188-194 °C(lit.)
Boiling Point:
539.4 °C at 760 mmHg
Flash Point:
280 °C
Hazard Symbols:
Xi
Risk Codes:
36/37/38-43
Safety Description:
26-36/37 Details
Transport Information:
UN 3249
particular:
particular

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Chemistry

IUPAC Name: 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
Molecular Formula: C₂₃H₃₆N₄O₁₀S₂
Molecular Weight: 592.69g/mol
EINECS: 205-424-1
Liansport Information: 5kgs
Melting Point: 188 - 194 °C
Boiling Point: 539.4°C at 760mmHg
Flash Point: 280°C
Appearance: white crystalline powder
Freely Rotating Bonds: 10
Polar Surface Area: 49.66 Å²
Polarizability: 10^-24 cm³
Enthalpy of Vaporization: 81.68 kJ/mol
Vapour Pressure: 1.06E-11 mmHg at 25°C
The chemical synonyms of Pentamidine isethionate (140-64-7) are 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt) ; 1,5-Bis[p-amidinophenoxy]pentane bis[2-hydroxyethanesulfonate salt] isethionate salt ; 4,4'-(Pentamethylenedioxy)dibenzamide bis(2-hydroxyethanesulfonate) ; 4,4'-(Pentamethylenedioxy)dibenzamidine, bis-2-hydroxyethanesulfonate ; Pentamidine isethionate ; Pentamidine isethionate salt ; 4,4'-(Pentamethylenedioxy)dibenzamidine bis 2-hyd ; Pentamidine isetionate .Product categories of Pentamidine isethionate (140-64-7) are API .The molecular structure of Pentamidine isethionate (140-64-7) is .

Uses

It can be used as raw material in pharmaceutical .

Toxicity Data With Reference

1.	dni-mus:leu 29,500 µg/L	INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. 1 (1983),103.
2.	ims-wmn TDLo:6 mg/kg/D:BLD,SKN	CANCAR Cancer. 34 (1974),441.
3.	ipr-mus LD50:63 mg/kg	ANTCAO Antibiotics and Chemotherapy. 2 (1952),581.
4.	scu-mus LD50:120 mg/kg	ANTCAO Antibiotics and Chemotherapy. 2 (1952),581.
5.	ivn-mus LD50:15,100 µg/kg	ANTCAO Antibiotics and Chemotherapy. 2 (1952),581.

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by intramuscular route: hemorrhage and dermatitis. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Hazard Codes: Xi
Xi: Irritant
Risk Statements: 36/37/38-43
36/37/38: Irritating to eyes, respiratory system and skin
43: May cause sensitization by skin contact
Safety Statements: 26-36/37
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37: Wear suitable protective clothing and gloves