Perindopril erbumine (107133-36-8),Perindopril erbumine (107133-36-8) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Perindopril erbumine
CAS No.:
107133-36-8
Molecular Structure:
Formula:
C₁₉H₃₂N₂O₅^.C₄H₁₁N
Molecular Weight:
441.69
Synonyms:
(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, compound with tert-butylamine (1:1);Aceon (TN);S 9490-3;Perindopril erbumine/tert-butylamine;Perindopril erbumine [USAN];(2S,3aS,7aS)-1-{(2S)-2-[(1S)-1-(ethoxycarbonyl)butylamino]propanoyl}octahydro-1H-indole-2-carboxylic acid--2-methylpropan-2-amine (1/1);(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-ethoxycarbonylbutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; 2-methylpropan-2-amine;S-9490-3;1H-Indole-2-carboxylic acid,1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)- butyl]amino]-1-oxopropyl]octahydro-,(2S,3aS,- 7aS)-,compd. with 2-methyl-2-propanamine (1:1);1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-, compd. with 2-methyl-2-propanamine (1:1);McN-A-2833-109;Perindopril erbumine (JAN/USAN);MCN-A 2833-109;Perindopril tert-butylamine;Perindopril;
Density:
1.15 g/cm³
Melting Point:
126-128 °C
Boiling Point:
537.4 °C at 760 mmHg
Flash Point:
278.8 °C
Appearance:
white solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety Description:
26-36 Details

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Chemistry

The Molecular Structure of Perindopril erbumine (CAS NO.107133-36-8):

Empirical Formula: C₁₉H₃₂N₂O₅
Molecular Weight: 368.4678
Nominal Mass: 368 Da
Average Mass: 368.4678 Da
Monoisotopic Mass: 368.231122 Da
Index of Refraction: 1.512
Molar Refractivity: 96.17 cm³
Molar Volume: 320.3 cm³
Surface Tension: 44.9 dyne/cm
Density: 1.15 g/cm³
Flash Point: 278.8 °C
Enthalpy of Vaporization: 89.06 kJ/mol
Boiling Point: 537.4 °C at 760 mmHg
Vapour Pressure: 5.63E-13 mmHg at 25°C
Synonyms: Perindopril ; Perindopril erbumine [USAN] ; (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, compound with
tert-butylamine (1:1) ; ACEON ; McN-A-2833-109 ; Perindopril erbumine ; Perindopril tert-butylamine ; S-9490-3 ; UNII-1964X464OJ ; 1H-Indole-2-carboxylic acid, 1-(2-((1-
(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-, compd. with 2-methyl-2-propanamine (1:1)

Uses

Perindopril erbumine (CAS NO.107133-36-8) can be used as anangiotensin-converting enzyme (ACE) inhibitor.

Toxicity Data With Reference

1.	orl-rat LD :>2500 mg/kg	YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147.
2.	ivn-rat LD50:323 mg/kg	YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147.
3.	orl-mus LD :>2500 mg/kg	YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147.
4.	ivn-mus LD50:323 mg/kg	YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147.

Safety Profile

A poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_xHazard codes: Xi Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing