The IUPAC name of Perphenazine is 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol. With the CAS registry number 58-39-9, it is also named as 1-Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-. The product's categories are Organics; Antagonists Forensic and Veterinary Standards; Chemical Structure; Dopaminergics; Drugs & Metabolites; Neat Compounds Drugs of Abuse; Neurotransmitters; Others. Besides, it is white crystalline powder, which should be stored at 2-8 °C. In addition, its molecular formula is C₂₁H₂₆ClN₃OS and molecular weight is 403.97.

The other characteristics of this product can be summarized as: (1)EINECS: 200-381-5; (2)ACD/LogP: 4.34; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 2.88; (5)ACD/LogD (pH 7.4): 4.21; (6)ACD/BCF (pH 5.5): 40.74; (7)ACD/BCF (pH 7.4): 863.6; (8)ACD/KOC (pH 5.5): 190.38; (9)ACD/KOC (pH 7.4): 4036; (10)#H bond acceptors: 4; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 7; (13)Index of Refraction: 1.626; (14)Molar Refractivity: 114.22 cm³; (15)Molar Volume: 322.3 cm³; (16)Surface Tension: 50.9 dyne/cm; (17)Density: 1.253 g/cm³; (18)Flash Point: 304.8 °C; (19)Melting Point: 97 °C; (20)Water Solubility: 28.3 mg/L at 24 °C; (21)Enthalpy of Vaporization: 91.32 kJ/mol; (22)Boiling Point: 580.4 °C at 760 mmHg; (23)Vapour Pressure: 2.6E-14 mmHg at 25 °C.

Production of Perphenazine: frist, you can use N-(2-Hydroxyethyl) piperazine to produce 1-(3-Chloropropyl)-4-(2-hydroxyethyl) piperazine by condensation with Trimethylene bromochloride. And then please use it to produce crude product by condensation with 2-Chlorophenothiazine. Afterwards, you will obtain this chemical after recrystallize it by the use of Ethyl acetate.

Uses of Perphenazine: this chemical is a typical antipsychotic drug to treat psychosis (e.g. in schizophrenics) and the manic phases of bipolar disorder. It also can be used to treat agitated depression (together with an antidepressant) in low doses. Furthermore, it can be used to produce 2-{4-[3-(2-Chloro-5-oxo-5H-5l4-phenothiazin-10-yl)-propyl]-πperazin-1-yl}-ethanol.



This reaction needs NaNO₂, HCl and H₂O for 2 hours. The yield is 95 %.

When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed. And it also may cause sensitization by skin contact. You should wear suitable protective clothing, gloves and eye/face protection. After contact with skin, please wash immediately with plenty of soap-suds. Moreover, in case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

People can use the following data to convert to the molecule structure.
(1)SMILES: Clc2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(CCO)CC4
(2)InChI: InChI=1/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
(3)InChIKey: RGCVKNLCSQQDEP-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
(5)Std. InChIKey: RGCVKNLCSQQDEP-UHFFFAOYSA-N

The toxicity data is as follows: