Phenothiazine

IUPAC Name: 10H-Phenothiazine
Synonyms of Phenothiazine (CAS NO.92-84-2): 10H-Phenothiazine ; 4-27-00-01214 (Beilstein Handbook Reference) ; AFI-Tiazin ; AI3-00038 ; Agrazine ; Antiverm ; BRN 0143237 ; Biverm ; CCRIS 5877 ; Caswell No. 652 ; Contaverm ; Dibenzo-1,4-thiazine ; Dibenzo-p-thiazine ; Dibenzoparathiazine ; Dibenzothiazine ; EINECS 202-196-5 ; ENT 38 ; EPA Pesticide Chemical Code 064501 ; Early bird wormer ; Feeno ; Fenothiazine ; Fenothiazine [Dutch] ; Fenotiazina ; Fenotiazina [INN-Spanish] ; Fenotiazina [Italian] ; Fenoverm ; Fentiazin ; HSDB 5279 ; Helmetina ; Lethelmin ; NSC 2037 ; Nemazene ; Nemazine ; Nexarbol ; Orimon ; Padophene ; Reconox ; Souframine ; Thiodifenylamine ; Thiodifenylamine [Dutch] ; Thiodiphenylamin ; Thiodiphenylamin [German] ; Thiodiphenylamine ; Tiodifenilamina ; Tiodifenilamina [Italian] ; UNII-GS9EX7QNU6 ; Vermitin ; Wurm-thional ; XL-50
CAS NO: 92-84-2
Classification Code: Agricultural Chemical ; Anti-Infective Agents ; Antiparasitic Agents ; Antiprotozoal Agents ; Drug / Therapeutic Agent ; Fungicide, bactericide, wood preservative ; Human Data ; Insecticide ; Mutation data ; Nematocide ; Reproductive Effect
Molecular Formula of Phenothiazine (CAS NO.92-84-2): C₁₂H₉NS
Molecular Weight: 199.2716
Molecular Structure:

Melting Point: 184 °C 
Polar Surface Area: 37.33 Å²
Index of Refraction: 1.674
Molar Refractivity: 60.69 cm³
Molar Volume: 161.5 cm³
Surface Tension: 52.5 dyne/cm
Density of Phenothiazine (CAS NO.92-84-2): 1.233 g/cm³
Flash Point: 178.2 °C
Enthalpy of Vaporization: 61.8 kJ/mol
Boiling Point: 371 °C at 760 mmHg
Vapour Pressure: 1.06E-05 mmHg at 25°C

 Phenothiazine(CAS NO.92-84-2) is mainly used as the efficient inhibitor for acrylic acid , acrylic esters, and methacrylic acid ester.
There are three main therapeutic applications of the phenothiazine(CAS NO.92-84-2) drugs:
(1) they have an antiemetic effect (stop vomiting);
(2) they are used with anesthetics, potent analgesics (pain relievers), and sedatives to permit their use in smaller doses; 
(3) they are used most widely to relieve anx-iety and tension in various severe mental and emotional disorders.

The production of Phenothiazines (CAS NO.92-84-2) involves heating the appropriate meta-substituted diphenylamine with sulfur and an iodine catalyst to close the ring. Treatment with the strong base sodium amide gives the anion on the ring nitrogen, which then displaces the chlorine of the appropriate second reactant.

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Poison by intravenous route. Moderately toxic to humans by ingestion. Experimental reproductive effects. An insecticide. Large doses, i.e., heavy exposure, may cause hemolytic anemia and toxic degeneration of the liver. Can cause skin irritation and photosensitization. Dangerous; when heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of SO_x and NO_x.
Hazard Codes: Xi,Xn,N
Risk Statements:  36/37/38-43-51/53-36/38-40-20/21/22
36/37/38:  Irritating to eyes, respiratory system and skin 
43:  May cause sensitization by skin contact 
51/53:  Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
36/38:  Irritating to eyes and skin 
20/21/22:  Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:  26-36-61-36/37/39-29-22
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 
29:  Do not empty into drains 
22:  Do not breathe dust
WGK Germany:  1
F:  8-23: Photosensitive. Sensitive to air. 
HS Code:  29343090
Hazardous Substances Data: 92-84-2(Hazardous Substances Data)

OSHA PEL: TWA 5 mg/m³ (skin)
ACGIH TLV: TWA 5 mg/m³ (skin)
NIOSH REL: (Phenothiazine) TWA 5 mg/m³ (skin)