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Phosphorus pentoxide

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Name

Phosphorus pentoxide

EINECS 215-236-1
CAS No. 1314-56-3 Density 2.46 g/cm3
PSA 145.79000 LogP 1.17880
Solubility Soluble in sulfuric acid. Insoluble in acetone and ammonia. Decomposes in water. Melting Point 340 °C(lit.)
Formula O10P4 Boiling Point 122 °C (1 mmHg)
Molecular Weight 283.89 Flash Point 340-360°C
Transport Information UN 1807 8/PG 2 Appearance white to yellow crystalline powder
Safety 22-26-45 Risk Codes 35
Molecular Structure Molecular Structure of 1314-56-3 (Phosphorus pentoxide) Hazard Symbols CorrosiveC
Synonyms

Nutrition,plantphosphorus Phosphorus;Phosphorpentoxid;Phospholus Pentoxide;Phosphoric Pentoxide;Phosphoric anhydride;

 

Phosphorus pentoxide Consensus Reports

Reported in EPA TSCA Inventory.

Phosphorus pentoxide Standards and Recommendations

DFG MAK: 1 mg/m3
DOT Classification:  8; Label: Corrosive

Phosphorus pentoxide Specification

The Phosphorus pentoxide, also known as Phosphoric acid anhydride, is the organic compound with the formula O10P4. It belongs to the product categories of Inorganic Chemicals; Inorganics; Element oxide. Its EINECS registry number is 215-236-1. With the CAS registry number 1314-56-3, its systematic name is Tricyclo[3.3.1.13,7]tetraphosphoxane 1,3,5,7-tetraoxide. This white crystalline solid is the anhydride of phosphoric acid. It is a powerful desiccant. Phosphorus pentoxide is not flammable. It reacts vigorously with water and water-containing substances like wood or cotton, liberates much heat and may even cause fire.

Physical properties of Phosphorus pentoxide: (1)ACD/LogP: 6.399; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 6.40; (4)ACD/LogD (pH 7.4): 6.40; (5)ACD/BCF (pH 5.5): 42989.39; (6)ACD/BCF (pH 7.4): 42989.39; (7)#H bond acceptors: 10; (8)Index of Refraction: 1.491; (9)Molar Refractivity: 33.323 cm3; (10)Molar Volume: 115.059 cm3; (11)Surface Tension: 84.367 dyne/cm; (12)Density: 2.467 g/cm3.

Preparation of Phosphorus pentoxide: Phosphorus pentoxide is prepared by burning elemental phosphorus with sufficient supply of air:
P4 + 5 O2 → P4O10

Uses of Phosphorus pentoxide: 
Phosphorus pentoxide is a potent dehydrating agent as indicated by the exothermic nature of its hydrolysis:
P4O10 + 6 H2O → 4 H3PO4 (–177 kJ)
However, its utility for drying is limited somewhat by its tendency to form a protective viscous coating that inhibits further dehydration by unspent material. A granular form of P4O10 is used in desiccators.

Consistent with its strong desiccating power, P4O10 is used in organic synthesis for dehydration. The most important application is for the conversion of amides into nitriles:
P4O10 + RC(O)NH2 → P4O9(OH)2 + RCN

The indicated coproduct P4O9(OH)2 is an idealized formula for undefined products resulting from the hydration of P4O10.
Alternatively, when combined with a carboxylic acid, the result is the corresponding anhydride:
P4O10 + RCO2H → P4O9(OH)2 + [RC(O)]2O

When you are using this chemical, please be cautious about it as the following:
This chemical may destroy living tissue on contact and may cause burns. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1S/O10P4/c1-11-5-12(2)8-13(3,6-11)10-14(4,7-11)9-12
(2)InChIKey: DLYUQMMRRRQYAE-UHFFFAOYSA-N
(3)Canonical SMILES : O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LC50 inhalation 61mg/m3/1H (61mg/m3) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE
Toxicologist. Vol. 1, Pg. 140, 1981.
mouse LC50 inhalation 271mg/m3/1H (271mg/m3) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: HEMORRHAGE
Toxicologist. Vol. 1, Pg. 140, 1981.
rabbit LC50 inhalation 1689mg/m3/1H (1689mg/m3) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE
Toxicologist. Vol. 1, Pg. 140, 1981.
rat LC50 inhalation 1217mg/m3/1H (1217mg/m3) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: HEMORRHAGE
Toxicologist. Vol. 1, Pg. 140, 1981.

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