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Name |
Piperazine citrate |
EINECS | 205-622-8 |
CAS No. | 144-29-6 | Density | 0.741[at 20℃] |
PSA | 336.44000 | LogP | -2.98660 |
Solubility | 54g/L at 24℃ | Melting Point |
183-187 °C |
Formula | 2(C6H8O7).3(C4H10N2) | Boiling Point | 812.2 °C at 760 mmHg |
Molecular Weight | 278.262 | Flash Point | 445 °C |
Transport Information | N/A | Appearance | White crystalline powder |
Safety | 26 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
Oxyzin (syrup);Oxucide;Ascarex Syrup;Parazine;Vermizine (elixir);Helmezine;Pipizan;Pinozan;Bryrel;Piperazine citrate salt;Tripiperazine dicitrate;Pin-Tega;Tasnon;Vermago;Multifuge; |
The Piperazine citrate, with the CAS registry number 144-29-6, is also known as Tripiperazine dicitrate. It belongs to the product category of Piperidines, Piperidones, Piperazines. Its EINECS number is 205-622-8. This chemical's molecular formula is 2(C6H8O7).3(C4H10N2) and molecular weight is 642.66. What's more, its systematic name is Piperazine 2-hydroxy-1,2,3-propanetricarboxylate (3:2). Its classification codes are: (1)Anthelmintics; (2)Anti-Infective Agents; (3)Antiparasitic Agents; (4)Drug / Therapeutic Agent; (5)Human Data.
Physical properties of Piperazine citrate are: (1)# of Rule of 5 Violations: 3; (2)ACD/LogD (pH 5.5): -9.95; (3)ACD/LogD (pH 7.4): -13.42; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 20; (9)#H bond donors: 14; (10)#Freely Rotating Bonds: 12; (11)Polar Surface Area: 336.44 Å2; (12)Flash Point: 445 °C; (13)Enthalpy of Vaporization: 134.43 kJ/mol; (14)Boiling Point: 812.2 °C at 760 mmHg; (15)Vapour Pressure: 1.51E-30 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing.
You can still convert the following datas into molecular structure:
(1)SMILES: OC(=O)C(O)(CC(O)=O)CC(O)=O.OC(=O)C(O)(CC(O)=O)CC(O)=O.C1CNCCN1.C1CNCCN1.C1CNCCN1
(2)Std. InChI: InChI=1S/2C6H8O7.3C4H10N2/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;3*1-2-6-4-3-5-1/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);3*5-6H,1-4H2
(3)Std. InChIKey: JDDHUROHDHPVIO-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | LDLo | oral | 260mg/kg/3D-I (260mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA BEHAVIORAL: HEADACHE | Lancet. Vol. 1, Pg. 895, 1967. |
infant | TDLo | unreported | 500mg/kg/2D (500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | Indian Pediatrics. Vol. 18, Pg. 71, 1981. |
man | TDLo | oral | 150mg/kg/5D (150mg/kg) | SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING | JAMA, Journal of the American Medical Association. Vol. 161, Pg. 515, 1956. |
mouse | LD50 | intraperitoneal | 3548mg/kg (3548mg/kg) | BEHAVIORAL: EXCITEMENT SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985. |
mouse | LD50 | oral | 8500mg/kg (8500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA | Journal of Medicinal Chemistry. Vol. 6, Pg. 336, 1963. |
mouse | LDLo | intravenous | 100mg/kg (100mg/kg) | Compilation of LD50 Values of New Drugs. | |
rabbit | LDLo | intravenous | 175mg/kg (175mg/kg) | Compilation of LD50 Values of New Drugs. | |
rat | LD50 | oral | 11200mg/kg (11200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Journal of Medicinal Chemistry. Vol. 6, Pg. 336, 1963. |