Basic information
- Name:
Pitavastatin calcium
- CAS No.:
147526-32-7
- Molecular Structure:
- Formula:
- (C25H23FNO4)2.Ca
- Molecular Weight:
- 880.98
- Synonyms:
- Bis((3R,5S,6E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate), monocalcium salt;6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, calcium salt (2:1), (S-(R*,S*-(E)))-;Pitavastatin hemicalcium;UNII-IYD54XEG3W;Livalo;CCRIS 8652;
- Boiling Point:
- 692 °C at 760 mmHg
- Flash Point:
- 372.3 °C
- Appearance:
- white to off-white powder
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Chemistry
Molecular structure of Pitavastatin calcium (CAS NO.147526-32-7) is:
Product Name: Pitavastatin calcium
CAS Registry Number: 147526-32-7
IUPAC Name: calcium(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
Molecular Weight: 880.983646 [g/mol]
Molecular Formula: (C25H23FNO4)2.Ca
H-Bond Donor: 4
H-Bond Acceptor: 12
Flash Point: 372.3 °C
Enthalpy of Vaporization: 106.48 kJ/mol
Boiling Point: 692 °C at 760 mmHg
Vapour Pressure: 4.21E-20 mmHg at 25°C
Product Categories: Active Pharmaceutical Ingredients;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;chemical
Uses
Pitavastatin calcium (CAS NO.147526-32-7) can be used as a competitive inhibitor of HMG-CoA reductase.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | oral | 100mg/kg (100mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING | Oyo Yakuri. Pharmacometrics. Vol. 56, Pg. 67, 1998. |
| rat | LDLo | oral | 500mg/kg (500mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Oyo Yakuri. Pharmacometrics. Vol. 56, Pg. 67, 1998. |
Specification
Pitavastatin calcium , its cas register number is 147526-32-7. It also can be called Bis((3R,5S,6E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate), monocalcium salt ; NK 104 ; CCRIS 8652 ; Livalo ; Pitavastatin hemicalcium ; UNII-IYD54XEG3W ; 6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, calcium salt (2:1), (S-(R*,S*-(E)))- .It is a white to off-white powder.