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Basic information

  • Name:

  • Poly(ethylene glycol)

  • CAS No.:

  • 25322-68-3

  • Molecular Structure:
  • Formula:
  • (C2H4O)mult.H2O
  • Deleted CAS:
  • 88077-80-9|886469-28-9|88747-22-2|90597-70-9|9081-95-2|9085-02-3|9085-03-4|952682-62-1|956217-69-9|959127-49-2|99264-61-6|99333-89-8
  • Synonyms:
  • Glycols,polyethylene (8CI);AlkoxE 130;Alkox E 30;Alkox E 30G;Alkox R 100;Alkox R 15;Alkox R 400;Alkox SW;AquaCalk TWB-P;Aquaffin;Badimol;Breox 20M;Breox PEG 300;CBP 20;Carbowax 14000;Carbowax 1450;Carbowax 1500;Carbowax 4500;Carbowax E 300;CarbowaxSentry NF;Cartaretin E;Cerasol 250A;Chemiox E20(C);Gligogum 4000;H 22;HM 500;HPEO 4250;IW;KPEG 6000;KleanPrep;L 6;Laprol 1001;SINOPOL PEG400;
  • Hazard Symbols:
  • IrritantXi
  • Risk Codes:
  • 36/38
  • Safety Description:
  • 26-36-24/25 Details
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Specification

The systematic name of Poly(ethylene glycol) is Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-. With the CAS registry number 25322-68-3, it is also named as PEG. The product's categories are Polymers; Optimization Reagents; Protein Structural Analysis; X-Ray Crystallography; Cosmetic Ingredients & Chemicals; Gas Chromatography; Packed GC; Stationary Phases, and the other registry numbers are 101677-86-5; 106186-24-7; 107502-63-6; 107529-96-4; 109550-27-8; 112384-37-9; 112895-21-3; 114323-93-2; 116549-90-7; 119219-06-6; 125223-68-9; 12676-74-3; etc. Besides, it is clear colorless viscous liquid or white waxy crystalline flakes, which should be stored in closed containers in a cool, dry place at 2-8 °C. In addition, its molecular formula is C2n+2H4n+6On+2.

The other characteristics of this product can be summarized as: (1)EINECS: 203-473-3; (2)Density: 1.27 g/mL at 25 °C; (3)Melting Point: 64-66 °C; (4)Boiling Point: >250 °C; (5)Flash Point: 171 °C; (6)Solubility: H2O: 50 mg/mL; (7)Vapor density: >1 (vs air); (8)Vapor pressure: <0.01 mm Hg ( 20 °C).

Preparation of Poly(ethylene glycol): this chemical can be prepared by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers. The reaction is catalyzed by acidic or basic catalysts.
HOCH2CH2OH + n(CH2CH2O) → HO(CH2CH2O)n+1H

Uses of Poly(ethylene glycol): this chemical is used in laxatives, skin creams, sexual lubricants. It is also used for the treatment of hepatitis C, neutropenia, vascular agent, lymphatic agent, and general tumor-imaging agent. Additionally, it can be used in the repair of motor neurons damaged in crush or laceration incidence in vivo and in vitro. It is used in automobiles and boats as a low-toxicity alternative.  And it cna be used as a dispersant in a number of toothpastes. Furthermore, it can be used for plasmid DNA isolation and protein crystallization as precipitant. It is used to create very high osmotic pressures. It is also commonly used for gas chromatography as a polar stationary phase. And it can be used to preserve objects that have been salvaged from underwater.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes and skin. Please avoid contact with skin and eyes. Moreover, in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing.

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3gm/kg (3000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
guinea pig LD50 oral 15700mg/kg (15700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 17gm/kg (17000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 19600mg/kg (19600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 22500mg/kg (22500mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
guinea pig LD50 oral 28gm/kg (28000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50900mg/kg (50900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 intraperitoneal 473mg/kg (473mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 21, Pg. 387, 1986.
mouse LD50 intraperitoneal 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intraperitoneal 7500mg/kg (7500mg/kg)   National Technical Information Service. Vol. AD628-313,
mouse LD50 intraperitoneal 8gm/kg (8000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intravenous 7900ug/kg (7.9mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970.
mouse LD50 intravenous 8550mg/kg (8550mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 intravenous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 oral 28915mg/kg (28915mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
mouse LD50 oral 31gm/kg (31000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 34gm/kg (34000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 36gm/kg (36000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 subcutaneous 18gm/kg (18000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD skin > 1gm/kg (1000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rabbit LD50 intravenous 8gm/kg (8000mg/kg) BLOOD: CHANGE IN CLOTTING FACTORS Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 4, Pg. 71, 1978.
rabbit LD50 oral 14gm/kg (14000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 17300mg/kg (17300mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 17300mg/kg (17300mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 19gm/kg (19000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 26800mg/kg (26800mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 76gm/kg (76000mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 76gm/kg (76000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 skin > 20mL/kg (20mL/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2202,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-96,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-939,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD oral > 4gm/kg (4000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rat LD50 intraperitoneal 6790mg/kg (6790mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9gm/kg (9000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9700mg/kg (9700mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 9708mg/kg (9708mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
rat LD50 intraperitoneal 12600mg/kg (12600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 14100mg/kg (14100mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 15390mg/kg (15390mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 15570mg/kg (15570mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 17gm/kg (17000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 intraperitoneal 17700mg/kg (17700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intravenous 7130mg/kg (7130mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 7312mg/kg (7312mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intravenous 7500mg/kg (7500mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 13gm/kg (13000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 600mg/kg (600mg/kg)   Dow Chemical Company Reports. Vol. MSD-94,
rat LD50 oral 1054mg/kg (1054mg/kg)   Dow Chemical Company Reports. Vol. MSD-95,
rat LD50 oral > 4gm/kg (4000mg/kg)   Dow Chemical Company Reports. Vol. MSD-938,
rat LD50 oral 22gm/kg (22000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 27500mg/kg (27500mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 28gm/kg (28000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rat LD50 oral 30gm/kg (30000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rat LD50 oral 30200mg/kg (30200mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 oral 31600mg/kg (31600mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 31640mg/kg (31640mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 32gm/kg (32000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rat LD50 oral 44200mg/kg (44200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 45gm/kg (45000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51200mg/kg (51200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51310mg/kg (51310mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 subcutaneous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 unreported 7800mg/kg (7800mg/kg)   United States Patent Document. Vol. #4767763,
rat LDLo intravenous 3mg/kg (3mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 442, 1970.
rat LDLo intravenous 22gm/kg (22000mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

KIDNEY, URETER, AND BLADDER: HEMATURIA		 Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1087, 1973.

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