Polymyxin B sulfate (1405-20-5),Polymyxin B sulfate (1405-20-5) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Polymyxin B sulfate
CAS No.:
1405-20-5
Molecular Structure:
Formula:
C₅₆H₉₈N₁₆O₁₃^.H₂SO₄
Molecular Weight:
1301.56
Synonyms:
Campho-Phenique Antibiotic Plus Pain Relief Ointment;Ophthocort;Neosporin Plus;Dexacidin;Neobacimyx (Veterinary);Polymixin B sulfate (JP14);Aerosporin (TN);Poly-Pred;Drotic;Pediotic Suspension;Statrol;2-[(4-amino-2-formamido-butanoyl)amino]-N-[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]-4-hydroxy-butanamide; sulfuric acid;Neosporin;Aerosporin;Chloromyxin;Otocort;Mastimyxin;
EINECS:
215-774-7
Solubility:
water: 50 mg/mL
Hazard Symbols:
Xn
Risk Codes:
22
Safety Description:
22-24/25 Details

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Chemistry

Molecular Formula: C₅₆H₁₀₀N₁₆O₁₇S
Molecular Weight: 1301.56
EINECS: 215-774-7
Flash Point: 952.3 °C
Enthalpy of Vaporization: 272.45 kJ/mol
Boiling Point: 1651 °C at 760 mmHg
Storage tempreture: 2-8 °C
Solubility: H₂O: 50 mg/mL
Form: Powder
Structure of Polymyxin B sulfate (CAS NO.1405-20-5):

Product Category of Polymyxin B sulfate (CAS NO.1405-20-5): Interferes with Cell Membrane Permeability (Ionophores)Spectrum of Activity;PeptidesCell Signaling and Neuroscience;Antibiotics;Reagents and Supplements

Uses

Polymyxin B sulfate (CAS NO.1405-20-5) is used for resistant gram negative infections as an antibiotic. In addition to its antibiotic function, it has been used to clear endotoxin contamination in reagents

Toxicity Data With Reference

1.	dnd-esc 50 mg/L	MUREAV Mutation Research. 89 (1981),95.
2.	orl-mus LD50:790 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
3.	ipr-mus LD50:20,500 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
4.	scu-mus LD50:59,500 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
5.	ivn-mus LD50:5400 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794.
6.	ivn-dog LDLo:8 mg/kg	INURAQ Investigative Urology. 6 (1969),505.
7.	ice-dog LDLo:320 µg/kg	BJPCAL British Journal of Pharmacology and Chemotherapy. 23 (1964),552.

Safety Profile

Poison by intravenous, subcutaneous, intraperitoneal and intracerebral routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x and NO_x. See also POLYMYXIN B.
Hazard Codes: Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.

Specification

Polymyxin B sulfate , its cas register number is 1405-20-5. It also can be called N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide sulfuric acid .