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Polyvinylpyrrolidone

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Polyvinylpyrrolidone

EINECS
CAS No. 9003-39-8 Density 1.144g/cm3
Solubility 10g/100mL at 2 °C Melting Point
Formula C6H9NO Boiling Point 217.6 °C at 760 mmHg
Molecular Weight 111.1418 Flash Point 93.9 °C
Transport Information Appearance white powder
Safety S22; S24/25 Risk Codes
Molecular Structure Molecular Structure of 9003-39-8 (Povidone) Hazard Symbols
Synonyms

2-Pyrrolidinone,1-vinyl-, polymers (8CI);1-Vinyl-2-pyrrolidinone polymer;1-Vinyl-2-pyrrolidone homopolymer;1-Vinyl-2-pyrrolidone polymer;Antitox Vana;Bolinan;Deltaspeed AF;Divergan F;Divergan RS;Hemodesis;Hemodez;N-Vinyl-2-pyrrolidinone homopolymer;N-Vinyl-2-pyrrolidonehomopolymer;N-Vinyl-2-pyrrolidone polymer;N-Vinylbutyrolactam polymer;N-Vinylpyrrolidinone polymer;N-Vinylpyrrolidone homopolymer;N-Vinylpyrrolidone polymer;Neohemodes;PV 03 (vinyl pyrrolidone polymer);Povidone/Polyvinylpyrrolidone(PVP);Polyvinylpyrrolidone;Povidone K-30;Povidone/PVP/POLYVINYL PYRROLIDONE;

 

Polyvinylpyrrolidone Consensus Reports

IARC Cancer Review: Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 19 ,1979,p. 461.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Polyvinylpyrrolidone Specification

Polyvinylpyrrolidon, with CAS number of 9003-39-8, is a kind of white powder. It can be called Povidone; PVP 3000; N-Vinylpyrrolidone polymer; N-Vinylbutyrolactam polymer; N-Vinylpyrrolidone homopolymer; N-Vinyl-2-pyrrolidone polymer and N-Vinyl-2-pyrrolidinone homopolymer. Polyvinylpyrrolidone should be stored in shady and cool warehouse and mainly used as pharmaceutical Intermediates.

Physical properties about Polyvinylpyrrolidon are: (1)ACD/LogP: 0.37; (2)ACD/LogD (pH 5.5): 0.37; (3)ACD/LogD (pH 7.4): 0.37; (4)ACD/BCF (pH 5.5): 1.13; (5)ACD/BCF (pH 7.4): 1.13; (6)ACD/KOC (pH 5.5): 37.87; (7)ACD/KOC (pH 7.4): 37.87; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.593 ; (11)Molar Refractivity: 32.924 cm3; (12)Molar Volume: 97.135 cm3; (13)Polarizability: 13.052 10-24cm3; (14)Surface Tension: 52.3899993896484 dyne/cm; (15)Density: 1.144 g/cm3; (16)Flash Point: 93.889 °C; (17)Enthalpy of Vaporization: 45.393 kJ/mol; (18)Boiling Point: 217.551 °C at 760 mmHg; (19)Vapour Pressure: 0.131999999284744 mmHg at 25°C

Uses of Polyvinylpyrrolidon: It is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. PVP is also used in many technical applications: as an adhesive in glue stick and hot-melt adhesives. Except, It is also used in the wine industry as a fining agent for white wine or some beers. Other references state that polyvinyl pyrrolidone and its derivatives are fully from mineral synthetic origin. Therefore, its use in the production should not be a problem for vegans.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C1N(\C=C)CCC1;
(2)Std. InChI:InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2;
(3)Std. InChIKey:WHNWPMSKXPGLAX-UHFFFAOYSA-N;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 100gm/kg (100000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 486, 1974.
mouse LD50 intraperitoneal 12gm/kg (12000mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 486, 1974.
mouse LD50 oral > 40gm/kg (40000mg/kg)   FAO Nutrition Meetings Report Series. Vol. 40, Pg. 164, 1967.
mouse LD50 unreported 16gm/kg (16000mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 19, Pg. 212, 1985.
mouse LDLo oral 3gm/kg (3000mg/kg)   Biomaterials, Medical Devices, and Artificial Organs. Vol. 12, Pg. 1, 1984.
 
mouse LDLo oral 3gm/kg (3000mg/kg)   Biomaterials, Medical Devices, and Artificial Organs. Vol. 12, Pg. 1, 1984.
 
mouse LDLo oral 5gm/kg (5000mg/kg)   Biomaterials, Medical Devices, and Artificial Organs. Vol. 12, Pg. 1, 1984.
 
rabbit LD50 oral 1040mg/kg (1040mg/kg)   Veterinariya. Veterinary Science. Vol. 61(12), Pg. 68, 1985.
rat LD50 oral 100gm/kg (100000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 486, 1974.

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