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Basic information

  • Name:

  • Pravastatin sodium

  • CAS No.:

  • 81131-70-6

  • Formula:
  • C23H35NaO7
  • Synonyms:
  • Mevalotin;Pravachol;Pravachol (TN);Pravastatine [French];1-Naphthaleneheptanoic acid,1,2,6,7,8,8a-hexahydro-a,?,6-trihydroxy- 2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-,monosodium salt,(aR,?R,1S,2S,6S,8S,8aR)-;Pravastatina [Spanish];Pravastatinum [Latin];1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betas*,deltas*),2alpha,6alpha,8beta(R*),8aalpha))-;sodium (3R,5R)-7-[(1S,2R,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoate;1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-((2S)-2-methyl-1-oxobutoxy)-, (betaR,deltaR,1S,2S,6S,8S,8aR)-;Lipostat;SQ 31000;Paravastatin;

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Chemistry

Molecular Structure of Pravastatin sodium (CAS NO.81131-70-6):

IUPAC Name: Sodium(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
Molecular Weight: 446.50957 [g/mol]
Molecular Formula: C23H35NaO7
H-Bond Donor: 3
H-Bond Acceptor: 7 
Appearance: White Crystalline Powder
Melting Point: 171.2-173 °C
storage temp.: 2-8 °C
solubility: H2O: 19 mg/mL 
Flash Point: 213.2 °C
Enthalpy of Vaporization: 107.45 kJ/mol
Boiling Point: 634.5 °C at 760 mmHg
Vapour Pressure: 9.15E-19 mmHg at 25 °C
Classification Code: Antihyperlipidemic; Drug / Therapeutic Agent; Human Data 
Product Categories: Active Pharmaceutical Ingredients; Antihyperlipoproteinemic; Various Metabolites and Impurities; Chiral Reagents; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals; HMG-CoA reductase

Uses

 Pravastatin sodium (CAS NO.81131-70-6) can be used as a competitive inhibitor of HMG-CoA reductase, Bioactive metabolite of Mevastatin

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 16mg/kg/8W-I (16mg/kg) LIVER: "JAUNDICE, CHOLESTATIC"

LIVER: LIVER FUNCTION TESTS IMPAIRED

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 American Journal of Emergency Medicine. Vol. 17, Pg. 1388, 1999.
mouse LD50 intravenous 2011mg/kg (2011mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
mouse LD50 oral 8939mg/kg (8939mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: CHANGES IN SPLEEN		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
mouse LD50 subcutaneous 2975mg/kg (2975mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
rat LD50 intravenous 440mg/kg (440mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
rat LD50 oral > 12gm/kg (12000mg/kg)   Yakkyoku. Pharmacy. Vol. 40, Pg. 2351, 1989.
rat LD50 subcutaneous 3172mg/kg (3172mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 4949, 1987.
rat LDLo intraperitoneal 400mg/kg (400mg/kg)   Biochemistry and Molecular Biology International. Vol. 47, Pg. 519, 1999.
women TDLo oral 16800ug/kg (16.8mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Lancet. Vol. 340, Pg. 910, 1992.
women TDLo oral 30mg/kg/21W-I (30mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 New England Journal of Medicine. Vol. 327, Pg. 649, 1992.

Safety Profile

Moderately toxic by intravenous and intraperitoneal. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety Information of Pravastatin sodium (CAS NO.81131-70-6):
Hazard Codes: FlammableF,CorrosiveC
Risk Statements: 11-34 
R11:Highly flammable. 
R34:Causes burns.
Safety Statements: 16-26-36/37/39-45 
S16:Keep away from sources of ignition. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 3077
WGK Germany: 2
RTECS: QJ7185000
HazardClass: 9
PackingGroup: III

Specification

  Pravastatin sodium (CAS NO.81131-70-6), its Synonyms are 3-beta-Hydroxycompactin sodium salt ; Aplactin ; Bristacol ; Pravachol ; Pravacol ; Pravaselect ; Pravasin ; Pravasine ; Pravastatin Natrium Mayrho Fer ; Sanaprav ; Selektine ; Selipran ; Sodium (+)-(betaR,deltaR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-beta,delta,6,8-tetrahydroxy-2-methyl-1-naphthaleneheptanoate, 8-((2S)-2-methylbutyrate) .

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