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Prednisolone-21-acetate
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Name

Prednisolone-21-acetate

 EINECS 200-134-1
CAS No. 52-21-1 Density 1.28 g/cm3
PSA 100.90000 LogP 2.12840
Solubility 11.6mg/L(25 oC) Melting Point 240-244 °C
Formula C23H30O6 Boiling Point 579.8 °C at 760 mmHg
Molecular Weight 402.488 Flash Point 198.4 °C
Transport Information UN 2811 6.1/PG 3 Appearance white crystalline powder
Safety 45-36/37/39-26-16 Risk Codes 25-34-11
Molecular Structure Molecular Structure of 52-21-1 (Prednisolone-21-acetate) Hazard Symbols ToxicT,CorrosiveC,FlammableF
Synonyms

Supercortyl;Prednisolone acetate;Prednidoren;Predicort;Pred-Forte;Pregna-1,4-diene-3,20-dione,11b,17,21-trihydroxy-, 21-acetate(6CI,7CI,8CI);11b,17a,21-Trihydroxypregna-1,4-diene-3,20-dione21-acetate;21-Acetoxy-11b,17-dihydroxypregna-1,4-diene-3,20-dione;Cormalone;Deltilen;Econopred;Falcon (steroid);Inflanefran;Meticortelone acetate;NSC 10966;Pred Mild;

Article Data 35

Prednisolone-21-acetate Synthetic route

50-24-8

prednisolon

108-24-7

acetic anhydride

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 40℃; for 0.5h; Inert atmosphere;99.8%
With pyridine98%
With pyridine
With dmap at 60 - 65℃; for 6h; Time;55.1 g
With sodium acetate In tetrahydrofuran; acetone at 40℃; for 3h; Reagent/catalyst; Inert atmosphere;
4224-31-1

21-acetoxy-9-bromo-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
Stage #1: 21-acetoxy-9-bromo-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione With chromium(VI) oxide; mercaptoacetic acid; zinc In dimethyl sulfoxide; acetone at 15 - 20℃;
Stage #2: With hydrogenchloride In water for 1h;
Stage #3: With sodium thiosulfate In water for 0.333333h; Reagent/catalyst;		92%
50-03-3

hydrocortisone acetate

A

52-21-1

prednisolone 21-acetate

B

120612-05-7

21,21'-diacetoxy-11β,17,11'β,17'-tetrahydroxy-2,2'-diselanediyl-bis-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With selenium(IV) oxide; acetic acid
28449-43-6

21-acetoxy-11β-hydroxy-pregna-1,4,17(20)c-trien-3-one

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene
21-acetoxy-1117β-dihydroxy-pregn-4-en-3,20-one

21-acetoxy-1117β-dihydroxy-pregn-4-en-3,20-one

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With selenium(IV) oxide
With iodine pentoxide
21-acetoxy-2α,4β-dibromo-11β,17-dihydroxy-5pregnane-3,20-dione

21-acetoxy-2α,4β-dibromo-11β,17-dihydroxy-5pregnane-3,20-dione

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With lithium carbonate; N,N-dimethyl-formamide; lithium bromide
24916-88-9

21-acetoxy-9-chloro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione

52-21-1

prednisolone 21-acetate

oxone

oxone

11β,17α-dihydroxy-20-phenoxypregna-1,4,20-trien-3-one

Oxone

Oxone

107-21-1

ethylene glycol

A

50-24-8

prednisolon

B

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With potassium hydroxide; sodium hydroxide In tetrahydrofuran; PO4; dichloromethane; water; acetone
...Expand
oxone

oxone

11β,17α-dihydroxy-20-phenoxypregna-1,4,20-trien-3-one

Oxone

Oxone

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With dmap; potassium hydroxide; sodium hydroxide; acetic anhydride; triethylamine In tetrahydrofuran; PO4; dichloromethane; water; acetone
With dmap; potassium hydroxide; sodium hydroxide; acetic anhydride; triethylamine In tetrahydrofuran; PO4; n-heptane; dichloromethane; water; acetone
96580-08-4

21-acetoxy-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione disemicarbazone

52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
Stage #1: 21-acetoxy-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione disemicarbazone With hydrogenchloride In chloroform; water at 25 - 30℃; for 0.5h;
Stage #2: With sodium nitrite In chloroform; water at 18 - 22℃; for 6h;		19.5 g

Prednisolone-21-acetate Chemical Properties

Product Name: [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Empirical Formula: C23H30O6
Molecular Weight: 402.4807
EINECS: 200-134-1 
Index of Refraction: 1.587
Density: 1.28 g/cm3
Flash Point: 198.4 °C
Melting point: 240-244 °C
Appearance: white crystalline powder
Enthalpy of Vaporization: 99.6 kJ/mol
Boiling Point: 579.8 °C at 760 mmHg
Vapour Pressure: 7.36E-16 mmHg at 25 °C
Structure of Prednisolone-21-acetate (CAS NO.52-21-1):
                       
Product Category of Prednisolone-21-acetate (CAS NO.52-21-1): Biochemistry;Hydroxyketosteroids;Steroids

Prednisolone-21-acetate Uses

 Prednisolone-21-acetate (CAS NO.52-21-1) can be applied to rheumatoid arthritis, rheumatic fever, lupus, scleroderma, dermatomyositis, acute lymphatic leukemia, and so on.

Prednisolone-21-acetate Toxicity Data With Reference

1.    

scu-mus TDLo:96 mg/kg (11D preg):TER

     SEIJBO    Senten Ijo. Congenital Anomalies. 13 (1973),245.
2.    

orl-rat TDLo:1800 mg/kg (2-19D preg):REP

     FESTAS    Fertility and Sterility. 22 (1971),735.
3.    

scu-mus LD50:3500 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),713.

Prednisolone-21-acetate Safety Profile

Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of Prednisolone-21-acetate (CAS NO.52-21-1): ToxicT,CorrosiveC,FlammableF
Risk Statements: 25-34-11
R11:Highly flammable. 
R25 :Toxic if swallowed. 
R34:Causes burns.
Safety Statements: 45-36/37/39-26-16 
S16:Keep away from sources of ignition. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Prednisolone-21-acetate Specification

 Prednisolone-21-acetate , its cas register number is 52-21-1. It also can be called Blephamide liquifilm ; Prednisolone acetate ; and 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate .

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