Basic information
- Name:
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-11,17-dihydroxy-, (11b)-
- Superlist Name:
- Prednisolone-21-acetate
- CAS No.:
52-21-1
- Molecular Structure:
- Formula:
- C23H30O6
- Molecular Weight:
- 402.53
- Synonyms:
- Supercortyl;Prednisolone acetate;Prednidoren;Predicort;Pred-Forte;Pregna-1,4-diene-3,20-dione,11b,17,21-trihydroxy-, 21-acetate(6CI,7CI,8CI);11b,17a,21-Trihydroxypregna-1,4-diene-3,20-dione21-acetate;21-Acetoxy-11b,17-dihydroxypregna-1,4-diene-3,20-dione;Cormalone;Deltilen;Econopred;Falcon (steroid);Inflanefran;Meticortelone acetate;NSC 10966;Pred Mild;
- EINECS:
- 200-134-1
- Density:
- 1.28 g/cm3
- Melting Point:
- 240-244 °C
- Boiling Point:
- 579.8 °C at 760 mmHg
- Flash Point:
- 198.4 °C
- Appearance:
- white crystalline powder
- Hazard Symbols:
T,
C,
F- Risk Codes:
- 25-34-11
- Safety Description:
- 45-36/37/39-26-16 Details
- Transport Information:
- UN 2811 6.1/PG 3
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Chemistry
Product Name: [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Empirical Formula: C23H30O6
Molecular Weight: 402.4807
EINECS: 200-134-1
Index of Refraction: 1.587
Density: 1.28 g/cm3
Flash Point: 198.4 °C
Melting point: 240-244 °C
Appearance: white crystalline powder
Enthalpy of Vaporization: 99.6 kJ/mol
Boiling Point: 579.8 °C at 760 mmHg
Vapour Pressure: 7.36E-16 mmHg at 25 °C
Structure of Prednisolone-21-acetate (CAS NO.52-21-1):
Product Category of Prednisolone-21-acetate (CAS NO.52-21-1): Biochemistry;Hydroxyketosteroids;Steroids
Uses
Prednisolone-21-acetate (CAS NO.52-21-1) can be applied to rheumatoid arthritis, rheumatic fever, lupus, scleroderma, dermatomyositis, acute lymphatic leukemia, and so on.
Toxicity Data With Reference
| 1. | scu-mus TDLo:96 mg/kg (11D preg):TER | SEIJBO Senten Ijo. Congenital Anomalies. 13 (1973),245. | ||
| 2. | orl-rat TDLo:1800 mg/kg (2-19D preg):REP | FESTAS Fertility and Sterility. 22 (1971),735. | ||
| 3. | scu-mus LD50:3500 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),713. |
Safety Profile
Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of Prednisolone-21-acetate (CAS NO.52-21-1): 
T,
C,
F
Risk Statements: 25-34-11
R11:Highly flammable.
R25 :Toxic if swallowed.
R34:Causes burns.
Safety Statements: 45-36/37/39-26-16
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Specification
Prednisolone-21-acetate , its cas register number is 52-21-1. It also can be called Blephamide liquifilm ; Prednisolone acetate ; and 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate .