Basic information
- Name:
Predonin
- CAS No.:
50-24-8
- Molecular Structure:
- Formula:
- C21H28O5
- Molecular Weight:
- 360.49
- Synonyms:
- Supercortisol;Codelcortone;Prestwick_404;Precortancyl;Cortalone;Dydeltrone;Fernisolone;Meti-Derm;Donisolone;K 1557;Paracortol;Cotogesic;Paracotol;Precortilon;Sterolone;Delcortol;Rolisone;Precortalon;Hydrodeltalone;Delta-Ef-Cortelan;Delta-cortef (TN);component of Ataraxoid;Prenolone;Cordrol;Hydeltra;(8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;Meticortelone;Deltacortenol;Sterane;Delta F;Precortisyl;Ulacort;Meticortelone;Sterolone;Deltisilone;Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-;Decortin H;1-Dehydrohydrocortisone;Prednis;Pregna-1,4-diene-3,20-dione,11,17,21- trihydroxy-,(11a)-;Predonine;Lentosone;1, 2-Dehydrohydrocortisone;Hydroretrocortin;Deltacortril;Di-Adreson F;Derpo PD;Deltahydrocortisone;Dexa-Cortidelt Hostacortin H;Hostacortin H;Scherisolon;Hydrodeltisone;Metacortandralone;Ultracortene-H;Ultracorten H;Fernisolone P;Prednisolone;
- EINECS:
- 200-021-7
- Density:
- 1.31 g/cm3
- Melting Point:
- 240 °C (dec.)(lit.)
- Boiling Point:
- 570.6 °C at 760 mmHg
- Flash Point:
- 313 °C
- Appearance:
- Crystalline Solid
- Hazard Symbols:
Xn, 
C, 
F- Risk Codes:
- 22-34-11
- Safety Description:
- 22-45-36/37/39-26-16 Details
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
.jpg)
IUPAC Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Molecular Weight: 360.44402 [g/mol]
Molecular Formula: C21H28O5
XLogP3: 1.6
H-Bond Donor: 3
H-Bond Acceptor: 5
EINECS: 200-021-7
Product Categories: Steroids; Steroids & Hormones - 13C & 2H; Antitumors for Research and Experimental Use; Biochemistry; Hydroxyketosteroids; Intermediates & Fine Chemicals; Pharmaceuticals
refractive index: 100 ° (C=1, Dioxane)
Index of Refraction: 1.611
Molar Refractivity: 95.48 cm3
Molar Volume: 274.7 cm3
Surface Tension: 60.7 dyne/cm
Density: 1.31 g/cm3
Flash Point: 313 °C
Enthalpy of Vaporization: 98.3 kJ/mol
Boiling Point: 570.6 °C at 760 mmHg
Vapour Pressure: 2.13E-15 mmHg at 25 °C
Water Solubility: 223 mg/L at 25 °C
Appearance: Crystalline Solid
Melting Point: 240 °C (dec.)(lit.)
Classification Code of Predonin (CAS NO.50-24-8): Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antineoplastic Agents; Antineoplastic agents, hormonal; Drug / Therapeutic Agent; Glucocorticoid; Glucocorticoids; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Mutation data; Reproductive Effect
Uses
Predonin (CAS NO.50-24-8) is commonly applicated for rheumatoid arthritis, rheumatic fever, lupus erythematosus, dermatomyositis, multiple myeloma, etc.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 9mg/kg/2W-I (9mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984. |
| mouse | LD50 | intraperitoneal | 65mg/kg (65mg/kg) | Indian Drugs. Vol. 22, Pg. 529, 1985. | |
| mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982. | |
| mouse | LD50 | oral | 1680mg/kg (1680mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 111, 1970. | |
| mouse | LD50 | subcutaneous | > 3500mg/kg (3500mg/kg) | Drugs in Japan Vol. 6, Pg. 710, 1982. | |
| rat | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | Advances in Teratology. Vol. 3, Pg. 181, 1968. | |
| rat | LD50 | intravenous | 120mg/kg (120mg/kg) | Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982. | |
| rat | LD50 | subcutaneous | 147mg/kg (147mg/kg) | Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. | |
| women | TDLo | oral | 14mg/kg/13D-I (14mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984. |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
A poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects by an unspecified route: developmental abnormalities of the central nervous system; effects on embryo or fetus: fetal death, extra embryonic structures. Human reproductive effects by an unspecified route: stillbirth. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: 
Xn,
C,
F
Risk Statements: 22-34-11
R22:Harmful if swallowed.
R34:Causes burns.
R11:Highly flammable.
Safety Statements: 22-45-36/37/39-26-16
S22:Do not breathe dust.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S16:Keep away from sources of ignition.
WGK Germany: 3
RTECS: TU4152000
Specification
Predonin (CAS NO.50-24-8), its Synonyms are (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione ; 1,2-Dehydrohydrocortisone ; 1,4-Pregnadien-11-beta,17-alpha,21-triol-3,20-dione ; 1,4-Pregnadiene-11-beta,17-alpha,21-triol-3,20-dione ; 1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione ; 1,4-Pregnadiene-3,20-dione-11-beta,17-alpha,21-triol ; 1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol ; 1-Dehydrohydrocortisone ; 11-beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione ; 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione ; 3,20-Dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene ; Prednisolone ; Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- ; Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy- (8CI) .