Basic information
- Name:
Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11b)-
- Superlist Name:
- Fluoromethalone
- CAS No.:
426-13-1
- Molecular Structure:
- Formula:
- C22H29FO4
- Molecular Weight:
- 376.47
- Synonyms:
- Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17-dihydroxy-6a-methyl- (6CI,7CI,8CI);21-Desoxy-9a-fluoro-6-methylprednisolone;6a-Methyl-9a-fluoro-11b,17a-dihydroxypregna-1,4-diene-3,20-dione;6a-Methyl-9a-fluoro-21-desoxyprednisolone;9a-Fluoro-11b,17a-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione;Cortilet;Delmeson;Efflumidex;FML;FML Forte;FML Liquifilm;FML SOP;Fluaton;FluatonPVA;Flumetholon;Flumetholone;Fluor-Op;Fluormetholon;Loticort;Oxylone;U 8614;Ursnon;
- EINECS:
- 207-041-5
- Density:
- 1.25 g/cm3
- Boiling Point:
- 527.1 °C at 760 mmHg
- Flash Point:
- 272.6 °C
- Hazard Symbols:
Xn- Risk Codes:
- 20/21/22
- Safety Description:
- 36 Details
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Chemistry
Molecular Structure:
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Molecular Formula: C22H29FO4
Molecular Weight: 376.4617
IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a] phenanthren-3-one
Synonyms of Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11b)- (CAS NO.426-13-1): Fluorometholone [INN:BAN:JAN] ; FML-S Liquifilm ; Neo-Oxylone ; 9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione ; 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione ; AI3-52813 ; Cortilet ; Delmeson ; EINECS 207-041-5 ; FML Forte ; FML Liquifilm ; FML S.O.P. ; Flumetholon ; Fluor-Op ; Fluormetholone ; Fluormetholonum ; Fluorometholone ; Fluorometholonum ; Fluorometholonum [INN-Latin] ; Fluorometolona ; Fluorometolona [INN-Spanish] ; Fluorometolone ; Fluorometolone [DCIT] ; Fml ; Oxylone ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl- ; Trilcin ; U 8614 ; UNII-SV0CSG527L ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
CAS NO: 426-13-1
Classification Code: Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Anti-allergic agents ; Drug / Therapeutic Agent ; Glucocorticoid ; Glucocorticoids ; Hormones ; Hormones, Hormone Substitutes, and Hormone Antagonists
Index of Refraction: 1.574
Molar Refractivity: 98.7 cm3
Molar Volume: 298.9 cm3
Surface Tension: 50.1 dyne/cm
Density: 1.25 g/cm3
Flash Point: 272.6 °C
Enthalpy of Vaporization: 92.22 kJ/mol
Boiling Point: 527.1 °C at 760 mmHg
Vapour Pressure of Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11b)- (CAS NO.426-13-1): 2.59E-13 mmHg at 25 °C
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD | oral | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974. | |
| rat | LD | subcutaneous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974. | |
| rat | LD50 | intraperitoneal | 443mg/kg (443mg/kg) | Drugs in Japan Vol. -, Pg. 981, 1990. |
Safety Profile
Hazard Codes of Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11b)- (CAS NO.426-13-1): 
Xn
Risk Statements:20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:36
S36: Wear suitable protective clothing.
WGK Germany:3
RTECS:TU3834100