NorarMepavine

Base Information

• Chemical Name: NorarMepavine
• CAS No.: 3195-01-5
• Molecular Formula: C18H21NO3
• Molecular Weight: 299.36400
• Hs Code.: 2933499090
• Mol file: 3195-01-5.mol

Synonyms:

Chemical Property of NorarMepavine

Chemical Property:

• Melting Point: 160-161℃
• PSA: 50.72000
• LogP: 3.16770

Purity/Quality:

99% ^*data from raw suppliers

Norarmepavine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NorarMepavine

There total 12 articles about NorarMepavine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1S,1'R)-1-(4-benzyloxybenzyl)-2-(2-hydroxy-1-phenylethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline → L-(-)-N-norarmepavine (3195-01-5,6392-40-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1248/cpb.39.1126

Reference yield:

1-(4-benzyloxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (655245-11-7) → L-(-)-N-norarmepavine (3195-01-5,6392-40-1)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 22h;

Reference yield:

1-(4-hydroxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline → L-(-)-N-norarmepavine (3195-01-5,6392-40-1)

Guidance literature:

With formic acid; Noyori's catalyst; triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03559

upstream raw materials:

1-(4-benzyloxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

2-(4-benzyloxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

1-(4-(benzyloxy)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline

Refernces

• 1、 Baxendale, Ian R.,Davidson, Thomas D.,Ley, Steven V.,Perni, Remedios H.. "Enantioselective synthesis of the tetrahydrobenzyl-isoquinoline alkaloid (-)-norarmepavine using polymer supported reagents". . p. 2707 - 2715. Retrieved 2007/10/03.