ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoate

Base Information

• Chemical Name: ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoate
• CAS No.: 328919-24-0
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Hs Code.: 2918990090
• Mol file: 328919-24-0.mol

Synonyms:ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoate; propanoic acid, 2-(3-hydroxyphenoxy)-2-methyl-, ethyl ester; LogP

Chemical Property of ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 334.222 °C at 760 mmHg
• Flash Point: 123.37 °C
• PSA: 55.76000
• Density: 1.133 g/cm³
• LogP: 2.11270

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(3-hydroxyphenoxy)-2-methylpropanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoate

There total 2 articles about ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl 2-bromoisobutyrate (600-00-0) + recorcinol (108-46-3) → 2-(3-hydroxy-phenoxy)-2-methyl-propionic acid ethyl ester (328919-24-0)

Guidance literature:

recorcinol; With ethanol; sodium; for 1h; Heating / reflux;

ethyl 2-bromoisobutyrate; In ethanol; for 3h; Heating / reflux;

With water; acetic acid;

Reference yield: 39.0%

→ 2-(3-hydroxy-phenoxy)-2-methyl-propionic acid ethyl ester (328919-24-0)

Guidance literature:

Reference yield: 80.0%

2-(3-hydroxy-phenoxy)-2-methyl-propionic acid ethyl ester (328919-24-0) + 3-{3-phenyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}-1-propanol (628330-03-0) → 2-methyl-2-[3-(3-{3-phenyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)phenoxy]propionic acid

Guidance literature:

2-(3-hydroxy-phenoxy)-2-methyl-propionic acid ethyl ester; 3-{3-phenyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}-1-propanol; With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 20 ℃;

With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; water;

upstream raw materials:

ethyl 2-bromoisobutyrate

recorcinol

Downstream raw materials:

ethyl 2-{3-[3-(1-benzyl-3-ethoxy-1H-pyrazol-4-yl)propoxy]phenoxy}-2-methylpropanoate

ethyl 2-{3-[4-(1-benzyl-3-ethoxy-1H-pyrazol-4-yl)butoxy]phenoxy}-2-methylpropanoate

2-{3-[2-(2-biphenyl-4-yl-5-methyloxazol-4-yl)ethoxy]phenoxy}-2-methylpropionic acid ethyl ester

2-{3-[2-(2-biphenyl-3-yl-5-methyloxazol-4-yl)ethoxy]phenoxy}-2-methylpropionic acid ethyl ester

Refernces

• 1、 -. "FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY". Page/Page column 43. . Retrieved 2010/10/20.
• 2、 -. "NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". Page/Page column 53. . Retrieved 2010/02/11.