Thiocyanic acid, 4-(acetylamino)phenyl ester

Base Information

• Chemical Name: Thiocyanic acid, 4-(acetylamino)phenyl ester
• CAS No.: 3321-94-6
• Molecular Formula: C9H8N2OS
• Molecular Weight: 192.241
• Mol file: 3321-94-6.mol

Synonyms:

Chemical Property of Thiocyanic acid, 4-(acetylamino)phenyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiocyanic acid, 4-(acetylamino)phenyl ester

There total 18 articles about Thiocyanic acid, 4-(acetylamino)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ammonium thiocyanate + Acetanilid (103-84-4) → N-(4-thiocyanatophenyl)acetamide (3321-94-6)

Guidance literature:

With trichloroisocyanuric acid; silica gel; In dichloromethane; at 20 ℃; for 0.25h; regioselective reaction;

DOI:10.1080/00397911.2010.537424

Reference yield: 97.0%

4-thiocyanatoaniline (2987-46-4) + acetic anhydride (108-24-7) → N-(4-thiocyanatophenyl)acetamide (3321-94-6)

Guidance literature:

In 1,4-dioxane;

Reference yield: 61.0%

copper(l) cyanide + 4-acetamidothiophenol (1126-81-4) → N-(4-thiocyanatophenyl)acetamide (3321-94-6)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1002/ejoc.201403279

upstream raw materials:

4-thiocyanatoaniline

acetic anhydride

trimethylsilyl cyanide

sodium 4-acetamidobenzenesulfinate

Downstream raw materials:

2-nitro-4-thiocyanoaniline

acetic acid-(2-nitro-4-thiocyanato-anilide)

(4-acetamidophenyl)disulfide

acetic acid-(2-chloro-4-thiocyanato-anilide)

Refernces

• 1、 Wang, Zhonghao,Wang, Liang,Chen, Qun,He, Ming-yang. "Rapid and efficient thiocyanation of phenols, indoles, and anilines in 1,1,1,3,3,3-hexafluoro-2-propanol under ultrasound irradiation". supporting information. p. 76 - 84. Retrieved 2017/12/28.
• 2、 Guo, Wei,Tan, Wen,Zhao, Mingming,Zheng, Lvyin,Tao, Kailiang,Chen, Deliang,Fan, Xiaolin. "Direct Photocatalytic S-H Bond Cyanation with Green cN Source". supporting information. p. 6580 - 6588. Retrieved 2018/05/29.