Deoxy Arteether

Base Information

• Chemical Name: Deoxy Arteether
• CAS No.: 112297-79-7
• Molecular Formula: C17H28 O4
• Molecular Weight: 296.4
• Mol file: 112297-79-7.mol

Synonyms:10aH-9,10b-Epoxypyrano[4,3,2-jk][2]benzoxepin,2-ethoxydecahydro-3,6,9-trimethyl-, [2S-(2a,3a,3ab,6b,6ab,9b,10aa,10bb)]-; Chemal 331; Deoxyarteether; Desoxyarteether A

Chemical Property of Deoxy Arteether

Chemical Property:

• Melting Point: 68-70?C
• PSA: 36.92000
• LogP: 3.29930
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

DEOXY ARTEETHER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Arteether. Artemisinin analogue; antimalarial agent. A metabolite of Arteether. Artemisinin analogue; antimalarial agent

Technology Process of Deoxy Arteether

There total 3 articles about Deoxy Arteether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

artemotil (75887-54-6) → deoxyarteether (112297-79-7)

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethanol; Ambient temperature;

DOI:10.1021/jm00398a026

Reference yield:

C12H13O2(CH3)3(O)(OO) (63968-64-9) → deoxyarteether (112297-79-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / sodium borohydride / methanol / 3 h / 0 - 5 °C

2: 72 percent / BF₃*Et₂O / benzene / 1 h / Heating

3: 69 percent / hydrogen / 5percent Pd/CaCO₃ / ethanol / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; Lindlar's catalyst; In methanol; ethanol; benzene;

DOI:10.1021/jm00398a026

Reference yield:

dihydroartemisinin (71939-50-9) → deoxyarteether (112297-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / BF₃*Et₂O / benzene / 1 h / Heating

2: 69 percent / hydrogen / 5percent Pd/CaCO₃ / ethanol / Ambient temperature

With boron trifluoride diethyl etherate; hydrogen; Lindlar's catalyst; In ethanol; benzene;

DOI:10.1021/jm00398a026

upstream raw materials:

artemotil

C₁₂H₁₃O₂(CH₃)3(O)(OO)

dihydroartemisinin

Refernces