N-(CHLOROACETYL)-4-FLUOROANILINE

Base Information

• Chemical Name: N-(CHLOROACETYL)-4-FLUOROANILINE
• CAS No.: 351-04-2
• Molecular Formula: C8H7ClFNO
• Molecular Weight: 187.601
• Hs Code.: 2921420090
• Mol file: 351-04-2.mol

Synonyms:Acetanilide,2-chloro-4'-fluoro- (8CI);2-Chloro-4'-fluoroacetanilide;2-Chloro-N-(4-fluorophenyl)acetamide;N-(Chloroacetyl)-4-fluoroaniline;

Chemical Property of N-(CHLOROACETYL)-4-FLUOROANILINE

Chemical Property:

• Melting Point: 131 °C
• Boiling Point: 336.2 °C at 760 mmHg
• Flash Point: 157.1 °C
• Density: 1.358 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(4-fluorophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Uses: 2-Chloro-N-(4-fluorophenyl)acetamide is used in diastereoselective synthesis.

Technology Process of N-(CHLOROACETYL)-4-FLUOROANILINE

There total 6 articles about N-(CHLOROACETYL)-4-FLUOROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloroacetyl chloride (79-04-9) + 4-fluoroaniline (371-40-4) → 2-chloro-N-(4-fluorophenyl)acetamide (351-04-2)

Guidance literature:

In ethyl acetate; for 3h; Heating;

Reference yield: 87.0%

→ 2-chloro-N-(4-fluorophenyl)acetamide (351-04-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield: 71.0%

4-fluoroaniline (371-40-4) + Chloroacetamide (79-07-2) → 2-chloro-N-(4-fluorophenyl)acetamide (351-04-2)

Guidance literature:

With pyridine; In benzene; at 20 - 60 ℃; for 5h;

DOI:10.1134/S1070428021020093

upstream raw materials:

chloroacetyl chloride

4-fluoroaniline

chloroacetyl isothiocyanate

Chloroacetamide

Downstream raw materials:

N-(4-fluorophenyl)-2-[(5-methylthien-3-yl)amino]-2-thioxoacetamide

N-(4-fluorophenyl)-2-[(2-oxo-3-(4-methylphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]-N-(4-fluorophenyl)acetamide

2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide

Refernces

• 1、 Bozdeveci, Arif,Krishna, Vagolu Siva,Sriram, Dharmarajan,Alpay Karao?lu, ?engül,Kü?ükgüzel, ?lkay,Kulaba?, Necla,Türe, Asl?. "Novel fluoroquinolones containing 2-arylamino-2-oxoethyl fragment: Design, synthesis, evaluation of antibacterial and antituberculosis activities and molecular modeling studies". . . Retrieved 2022/01/11.
• 2、 Abdalla, Ashraf N.,Almalki, Faisal A.,El Hassab, Mahmoud A.,Gouda, Ahmed M.,Shawky, Ahmed M.. "In silico approach using free software to optimize the antiproliferative activity and predict the potential mechanism of action of pyrrolizine-based schiff bases". . . Retrieved 2021/07/17.