N-MethyltrifluoroMethanesulfonaMide

Base Information

• Chemical Name: N-MethyltrifluoroMethanesulfonaMide
• CAS No.: 34310-29-7
• Molecular Formula: C2H4F3NO2S
• Molecular Weight: 163.12
• Hs Code.: 2935009090
• Mol file: 34310-29-7.mol

Synonyms:Methanesulfonamide, 1,1,1-trifluoro-N-methyl-;

Chemical Property of N-MethyltrifluoroMethanesulfonaMide

Chemical Property:

• Boiling Point: 119.6±50.0 °C at 760 mmHg
• PKA: 7.56±0.40(Predicted)
• Flash Point: 26.1±30.1 °C
• PSA: 54.55000
• Density: 1.5±0.1 g/cm³
• LogP: 1.52710

Purity/Quality:

98% ^*data from raw suppliers

N-Methyl-trifluoromethanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-MethyltrifluoroMethanesulfonaMide

There total 7 articles about N-MethyltrifluoroMethanesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trifluoromethylsulfonic anhydride (358-23-6) + methylamine hydrochloride (593-51-1) → N-methyltrifluoromethanesulfonamide (34310-29-7)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.7b13492

Reference yield: 72.0%

trifluoromethane sulfonyl chloride (421-83-0) + methylamine hydrochloride (593-51-1) → N-methyltrifluoromethanesulfonamide (34310-29-7)

Guidance literature:

trifluoromethane sulfonyl chloride; methylamine hydrochloride; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With sodium hydroxide; In water; at 0 ℃; for 2h;

DOI:10.1002/anie.201901673

Reference yield: 57.0%

trifluoromethylsulfonic anhydride (358-23-6) + methylamine (74-89-5) → N-methyltrifluoromethanesulfonamide (34310-29-7)

Guidance literature:

In dichloromethane; at -70 ℃; for 3h;

DOI:10.1016/S0040-4020(01)85630-1

upstream raw materials:

Trifluoromethanesulfonyl fluoride

methylamine

trifluoromethane sulfonyl chloride

trifluoromethylsulfonic anhydride

Downstream raw materials:

N-benzyl-N-methyl triflamide

(S)-(+)-3-<(N-methyl-N-trifluoromethanesulfonyl)amino>-1-butanol benzoate

(R)-(-)-3-<(N-methyl-N-trifluoromethanesulfonyl)amino>-1-butanol benzoate

Benzoic acid 3-(methyl-trifluoromethanesulfonyl-amino)-butyl ester

Refernces

• 1、 Ashley, Melissa A.,Yamauchi, Chiaki,Chu, John C. K.,Otsuka, Shinya,Yorimitsu, Hideki,Rovis, Tomislav. "Photoredox-Catalyzed Site-Selective α-C(sp3)?H Alkylation of Primary Amine Derivatives". supporting information. p. 4002 - 4006. Retrieved 2019/02/24.
• 2、 Ma, Rulin,Christina White. "C-H to C-N Cross-Coupling of Sulfonamides with Olefins". supporting information. p. 3202 - 3205. Retrieved 2018/03/13.