Benzoyl fluoride, 4-methyl-

Base Information

• Chemical Name: Benzoyl fluoride, 4-methyl-
• CAS No.: 350-42-5
• Molecular Formula: C8H7FO
• Molecular Weight: 138.141
• Mol file: 350-42-5.mol

Synonyms:

Chemical Property of Benzoyl fluoride, 4-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoyl fluoride, 4-methyl-

There total 15 articles about Benzoyl fluoride, 4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-Toluic acid (99-94-5) → 4-methylbenzoyl fluoride (350-42-5)

Guidance literature:

With trichloroisocyanuric acid; triphenylphosphine; cesium fluoride; In acetonitrile; at 20 ℃; for 24h; Reagent/catalyst; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c04087

Reference yield: 83.0%

4-Methyl-benzoic acid difluoromethyl ester (120608-85-7) → formyl fluoride (1493-02-3) + 4-methylbenzoyl fluoride (350-42-5)

Guidance literature:

With potassium fluoride; In 1,4-dioxane; at 110 ℃; for 10h;

DOI:10.1021/jo00274a012

Reference yield: 80.0%

4-methyl-benzoyl chloride (874-60-2) → 4-methylbenzoyl fluoride (350-42-5)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; for 4h;

upstream raw materials:

4-Methylbenzyl alcohol

carbon monoxide

para-bromotoluene

4-methyl-benzaldehyde

Downstream raw materials:

S-(p-tolyl) p-methylbenzothioathe

N-benzyl-4-methylbenzamide

(4-methylphenyl)triethylsilane

N-(p-methylbenzoyl)-α-methylbenzyl amine

Refernces

• 1、 Leclerc, Matthew C.,Bayne, Julia M.,Lee, Graham M.,Gorelsky, Serge I.,Vasiliu, Monica,Korobkov, Ilia,Harrison, Daniel J.,Dixon, David A.,Baker, R. Tom. "Perfluoroalkyl Cobalt(III) Fluoride and Bis(perfluoroalkyl) Complexes: Catalytic Fluorination and Selective Difluorocarbene Formation". . p. 16064 - 16073. Retrieved 2015.
• 2、 Ishikawa,Sasaki. "". . p. 1407,1408. Retrieved 1976.
• 3、 Barbasiewicz, Micha?,Tryniszewski, Micha?. "Gram-Scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles". . . Retrieved 2021/11/30.
• 4、 Brittain, William D. G.,Cobb, Steven L.. "Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)". supporting information. p. 5793 - 5798. Retrieved 2021/08/01.